Cell atlas - AGPAT1 - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

AGPAT1

TISSUE

premium

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Endoplasmic reticulum
	Rods & Rings

Human cell
	Cytosol
	Endoplasmic Reticulum

Please wait until image is loaded before changing channels

GENERAL INFORMATION
Gene name	AGPAT1
Gene description	1-acylglycerol-3-phosphate O-acyltransferase 1
Protein class	Enzymes Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	6
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the endoplasmic reticulum. In addition localized to the rods & rings.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Endoplasmic reticulum (supported)
Additional location	In addition localized to the Rods & Rings (approved)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA048478
	SHOW MORE

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the endoplasmic reticulum. In addition localized to the rods & rings.

Main location

Endoplasmic reticulum (supported)

Additional location

Rods & Rings (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA048478	SK-MEL-30	Endoplasmic reticulum
	HPA048478	U-2 OS	Endoplasmic reticulum
	HPA048478	U-2 OS	Rods & Rings

GENE INFORMATION
Gene name	AGPAT1 (HGNC Symbol)
Synonyms	LPAAT-alpha
Description	1-acylglycerol-3-phosphate O-acyltransferase 1 (HGNC Symbol)
Entrez gene summary	This gene encodes an enzyme that converts lysophosphatidic acid (LPA) into phosphatidic acid (PA). LPA and PA are two phospholipids involved in signal transduction and in lipid biosynthesis in cells. This enzyme localizes to the endoplasmic reticulum. This gene is located in the class III region of the human major histocompatibility complex. Alternative splicing results in two transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
Chromosome	6
Cytoband	p21.32
Chromosome location (bp)	32168212 - 32178096
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000204310 (version 83.38)
Entrez gene	10554
UniProt	Q99943 (UniProt - Evidence at protein level)
neXtProt	NX_Q99943
Antibodypedia	AGPAT1 antibodies

PROTEIN BROWSER

AGPAT1-001	AGPAT1-003	AGPAT1-004	AGPAT1-005	AGPAT1-006	AGPAT1-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
AGPAT1-001 ENSP00000337463 ENST00000336984	Q99943 [Direct mapping] 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha A0A024RCV5 [Target identity:100%; Query identity:100%] 1-acyl-sn-glycerol-3-phosphate acyltransferase Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001819 [positive regulation of cytokine production] GO:0001961 [positive regulation of cytokine-mediated signaling pathway] GO:0003841 [1-acylglycerol-3-phosphate O-acyltransferase activity] GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006112 [energy reserve metabolic process] GO:0006644 [phospholipid metabolic process] GO:0006654 [phosphatidic acid biosynthetic process] GO:0008152 [metabolic process] GO:0008654 [phospholipid biosynthetic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016024 [CDP-diacylglycerol biosynthetic process] GO:0016746 [transferase activity, transferring acyl groups] GO:0019432 [triglyceride biosynthetic process] GO:0031325 [positive regulation of cellular metabolic process] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0046474 [glycerophospholipid biosynthetic process] Show all	283 aa 31.7 kDa	Yes	2
AGPAT1-003 ENSP00000364245 ENST00000375104	Q99943 [Direct mapping] 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha A0A024RCV5 [Target identity:100%; Query identity:100%] 1-acyl-sn-glycerol-3-phosphate acyltransferase Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0001819 [positive regulation of cytokine production] GO:0001961 [positive regulation of cytokine-mediated signaling pathway] GO:0003841 [1-acylglycerol-3-phosphate O-acyltransferase activity] GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006112 [energy reserve metabolic process] GO:0006644 [phospholipid metabolic process] GO:0006654 [phosphatidic acid biosynthetic process] GO:0008152 [metabolic process] GO:0008654 [phospholipid biosynthetic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016024 [CDP-diacylglycerol biosynthetic process] GO:0016746 [transferase activity, transferring acyl groups] GO:0019432 [triglyceride biosynthetic process] GO:0031325 [positive regulation of cellular metabolic process] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0046474 [glycerophospholipid biosynthetic process] Show all	283 aa 31.7 kDa	Yes	2
AGPAT1-004 ENSP00000364248 ENST00000375107	Q99943 [Direct mapping] 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha A0A024RCV5 [Target identity:100%; Query identity:100%] 1-acyl-sn-glycerol-3-phosphate acyltransferase Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001819 [positive regulation of cytokine production] GO:0001961 [positive regulation of cytokine-mediated signaling pathway] GO:0003841 [1-acylglycerol-3-phosphate O-acyltransferase activity] GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006112 [energy reserve metabolic process] GO:0006644 [phospholipid metabolic process] GO:0006654 [phosphatidic acid biosynthetic process] GO:0008152 [metabolic process] GO:0008654 [phospholipid biosynthetic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016024 [CDP-diacylglycerol biosynthetic process] GO:0016746 [transferase activity, transferring acyl groups] GO:0019432 [triglyceride biosynthetic process] GO:0031325 [positive regulation of cellular metabolic process] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0046474 [glycerophospholipid biosynthetic process] Show all	283 aa 31.7 kDa	Yes	2
AGPAT1-005 ENSP00000378875 ENST00000395497	Q99943 [Direct mapping] 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha A0A024RCV5 [Target identity:100%; Query identity:100%] 1-acyl-sn-glycerol-3-phosphate acyltransferase Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0001819 [positive regulation of cytokine production] GO:0001961 [positive regulation of cytokine-mediated signaling pathway] GO:0003841 [1-acylglycerol-3-phosphate O-acyltransferase activity] GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006112 [energy reserve metabolic process] GO:0006644 [phospholipid metabolic process] GO:0006654 [phosphatidic acid biosynthetic process] GO:0008152 [metabolic process] GO:0008654 [phospholipid biosynthetic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016024 [CDP-diacylglycerol biosynthetic process] GO:0016746 [transferase activity, transferring acyl groups] GO:0019432 [triglyceride biosynthetic process] GO:0031325 [positive regulation of cellular metabolic process] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0046474 [glycerophospholipid biosynthetic process] Show all	283 aa 31.7 kDa	Yes	2
AGPAT1-006 ENSP00000378877 ENST00000395499	Q99943 [Direct mapping] 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha A0A024RCV5 [Target identity:100%; Query identity:100%] 1-acyl-sn-glycerol-3-phosphate acyltransferase Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0001819 [positive regulation of cytokine production] GO:0001961 [positive regulation of cytokine-mediated signaling pathway] GO:0003841 [1-acylglycerol-3-phosphate O-acyltransferase activity] GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006112 [energy reserve metabolic process] GO:0006644 [phospholipid metabolic process] GO:0006654 [phosphatidic acid biosynthetic process] GO:0008152 [metabolic process] GO:0008654 [phospholipid biosynthetic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016024 [CDP-diacylglycerol biosynthetic process] GO:0016746 [transferase activity, transferring acyl groups] GO:0019432 [triglyceride biosynthetic process] GO:0031325 [positive regulation of cellular metabolic process] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0046474 [glycerophospholipid biosynthetic process] Show all	283 aa 31.7 kDa	Yes	2
AGPAT1-008 ENSP00000378874 ENST00000395496	Q99943 [Direct mapping] 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha A0A024RCV5 [Target identity:100%; Query identity:100%] 1-acyl-sn-glycerol-3-phosphate acyltransferase Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0001819 [positive regulation of cytokine production] GO:0001961 [positive regulation of cytokine-mediated signaling pathway] GO:0003841 [1-acylglycerol-3-phosphate O-acyltransferase activity] GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006112 [energy reserve metabolic process] GO:0006644 [phospholipid metabolic process] GO:0006654 [phosphatidic acid biosynthetic process] GO:0008152 [metabolic process] GO:0008654 [phospholipid biosynthetic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016024 [CDP-diacylglycerol biosynthetic process] GO:0016746 [transferase activity, transferring acyl groups] GO:0019432 [triglyceride biosynthetic process] GO:0031325 [positive regulation of cellular metabolic process] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0046474 [glycerophospholipid biosynthetic process] Show all	283 aa 31.7 kDa	Yes	2

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.