Expression of STK19 in cancer - Summary - The Human Protein Atlas

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STK19

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	STK19
Gene description	Serine/threonine kinase 19
Protein class	Cancer-related genes Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (HDLM-2, REH)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification.
Reliability score	Uncertain based on 2 antibodies. HPA031510 , HPA031511
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PROGNOSTIC SUMMARY
Prognostic marker in melanoma (unfavourable).
Melanoma p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA031510	HPA031511

GENE INFORMATION
Gene name	STK19 (HGNC Symbol)
Synonyms	D6S60, G11, RP1
Description	Serine/threonine kinase 19 (HGNC Symbol)
Entrez gene summary	This gene encodes a serine/threonine kinase which localizes predominantly to the nucleus. Its specific function is unknown; it is possible that phosphorylation of this protein is involved in transcriptional regulation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6 and expresses two transcript variants. [provided by RefSeq, Jul 2008]
Chromosome	6
Cytoband	p21.33
Chromosome location (bp)	31971091 - 31982821
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000204344 (version 83.38)
Entrez gene	8859
UniProt	P49842 (UniProt - Evidence at protein level)
neXtProt	NX_P49842
Antibodypedia	STK19 antibodies

PROTEIN BROWSER

STK19-001	STK19-002	STK19-015

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
STK19-001 ENSP00000364480 ENST00000375331	P49842 [Direct mapping] Serine/threonine-protein kinase 19 Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0004674 [protein serine/threonine kinase activity] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0006468 [protein phosphorylation] Show all	364 aa 40.5 kDa	No	0
STK19-002 ENSP00000364482 ENST00000375333	P49842 [Direct mapping] Serine/threonine-protein kinase 19 Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0004674 [protein serine/threonine kinase activity] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0006468 [protein phosphorylation] Show all	368 aa 40.9 kDa	No	0
STK19-015 ENSP00000418350 ENST00000460018	C9J6S8 [Direct mapping] Serine/threonine-protein kinase 19 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all		112 aa 12.3 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.