Expression of SDHD in cancer - Summary - The Human Protein Atlas

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SDHD

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	SDHD
Gene description	Succinate dehydrogenase complex, subunit D, integral membrane protein
Protein class	Cancer-related genes Citric acid cycle related proteins Disease related genes FDA approved drug targets Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA045727
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA045727

GENE INFORMATION
Gene name	SDHD (HGNC Symbol)
Synonyms	PGL, PGL1
Description	Succinate dehydrogenase complex, subunit D, integral membrane protein (HGNC Symbol)
Entrez gene summary	This gene encodes a member of complex II of the respiratory chain, which is responsible for the oxidation of succinate. The encoded protein is one of two integral membrane proteins anchoring the complex to the matrix side of the mitochondrial inner membrane. Mutations in this gene are associated with the formation of tumors, including hereditary paraganglioma. Transmission of disease occurs almost exclusively through the paternal allele, suggesting that this locus may be maternally imprinted. There are pseudogenes for this gene on chromosomes 1, 2, 3, 7, and 18. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2013]
Chromosome	11
Cytoband	q23.1
Chromosome location (bp)	112086773 - 112120013
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000204370 (version 83.38)
Entrez gene	6392
UniProt	O14521 (UniProt - Evidence at protein level)
neXtProt	NX_O14521
Antibodypedia	SDHD antibodies

PROTEIN BROWSER

SDHD-001	SDHD-002	SDHD-003	SDHD-004	SDHD-005	SDHD-006	SDHD-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SDHD-001 ENSP00000364699 ENST00000375549	O14521 [Direct mapping] Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Citric acid cycle related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000104 [succinate dehydrogenase activity] GO:0005739 [mitochondrion] GO:0005740 [mitochondrial envelope] GO:0005743 [mitochondrial inner membrane] GO:0005749 [mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)] GO:0006099 [tricarboxylic acid cycle] GO:0009055 [electron carrier activity] GO:0016021 [integral component of membrane] GO:0020037 [heme binding] GO:0022904 [respiratory electron transport chain] GO:0044237 [cellular metabolic process] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] GO:0048039 [ubiquinone binding] Show all	159 aa 17 kDa	Yes	2
SDHD-002 ENSP00000435475 ENST00000528182	E9PK73 [Direct mapping] Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Citric acid cycle related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005740 [mitochondrial envelope] GO:0016021 [integral component of membrane] Show all	131 aa 14.4 kDa	Yes	1
SDHD-003 ENSP00000436217 ENST00000528048	O14521 [Direct mapping] Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Citric acid cycle related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014) Show all	GO:0000104 [succinate dehydrogenase activity] GO:0005739 [mitochondrion] GO:0005740 [mitochondrial envelope] GO:0005743 [mitochondrial inner membrane] GO:0005749 [mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)] GO:0006099 [tricarboxylic acid cycle] GO:0009055 [electron carrier activity] GO:0016021 [integral component of membrane] GO:0020037 [heme binding] GO:0022904 [respiratory electron transport chain] GO:0044237 [cellular metabolic process] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] GO:0048039 [ubiquinone binding] Show all	85 aa 9.7 kDa	Yes	0
SDHD-004 ENSP00000432465 ENST00000528021	G3V173 [Direct mapping] Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial; Succinate dehydrogenase complex, subunit D, integral membrane protein, isoform CRA_c Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Citric acid cycle related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005740 [mitochondrial envelope] GO:0016021 [integral component of membrane] Show all	104 aa 11.1 kDa	Yes	1
SDHD-005 ENSP00000436669 ENST00000525291	O14521 [Direct mapping] Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Citric acid cycle related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014) Show all	GO:0000104 [succinate dehydrogenase activity] GO:0005739 [mitochondrion] GO:0005740 [mitochondrial envelope] GO:0005743 [mitochondrial inner membrane] GO:0005749 [mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)] GO:0006099 [tricarboxylic acid cycle] GO:0009055 [electron carrier activity] GO:0016021 [integral component of membrane] GO:0020037 [heme binding] GO:0022904 [respiratory electron transport chain] GO:0044237 [cellular metabolic process] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] GO:0048039 [ubiquinone binding] Show all	120 aa 12.6 kDa	Yes	1
SDHD-006 ENSP00000432005 ENST00000526592	O14521 [Direct mapping] Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Citric acid cycle related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014) Show all	GO:0000104 [succinate dehydrogenase activity] GO:0005739 [mitochondrion] GO:0005740 [mitochondrial envelope] GO:0005743 [mitochondrial inner membrane] GO:0005749 [mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)] GO:0006099 [tricarboxylic acid cycle] GO:0009055 [electron carrier activity] GO:0016021 [integral component of membrane] GO:0020037 [heme binding] GO:0022904 [respiratory electron transport chain] GO:0044237 [cellular metabolic process] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] GO:0048039 [ubiquinone binding] Show all	143 aa 15.4 kDa	Yes	1
SDHD-201 ENSP00000480666 ENST00000614349	O14521 [Direct mapping] Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Citric acid cycle related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014) Show all	GO:0000104 [succinate dehydrogenase activity] GO:0005739 [mitochondrion] GO:0005740 [mitochondrial envelope] GO:0005743 [mitochondrial inner membrane] GO:0005749 [mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)] GO:0006099 [tricarboxylic acid cycle] GO:0009055 [electron carrier activity] GO:0016021 [integral component of membrane] GO:0020037 [heme binding] GO:0022904 [respiratory electron transport chain] GO:0044237 [cellular metabolic process] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] GO:0048039 [ubiquinone binding] Show all	143 aa 15.4 kDa	Yes	1

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