Expression of SLC44A4 in cancer - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

SLC44A4

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	SLC44A4
Gene description	Solute carrier family 44, member 4
Protein class	Disease related genes Potential drug targets Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	4
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (prostate cancer)
HPA (cell line):	Cell line enhanced (Hep G2)
HPA (normal tissue):	Tissue enhanced (duodenum)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Membranous expression in several tissues, including prostate.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 2 antibodies. HPA046977 , HPA054176
	SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable), head and neck cancer (favourable) and urothelial cancer (favourable).
Renal cancer p<0.001 Head and neck cancer p<0.001 Urothelial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (prostate cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA046977	HPA054176

GENE INFORMATION
Gene name	SLC44A4 (HGNC Symbol)
Synonyms	C6orf29, CTL4, FLJ14491, NG22, TPPT
Description	Solute carrier family 44, member 4 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene may be a sodium-dependent transmembrane transport protein involved in the uptake of choline by cholinergic neurons. Defects in this gene can cause sialidosis, a lysosomal storage disease. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2010]
Chromosome	6
Cytoband	p21.33
Chromosome location (bp)	31863192 - 31879046
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000204385 (version 83.38)
Entrez gene	80736
UniProt	Q53GD3 (UniProt - Evidence at transcript level)
neXtProt	NX_Q53GD3
Antibodypedia	SLC44A4 antibodies

PROTEIN BROWSER

SLC44A4-001	SLC44A4-004	SLC44A4-201	SLC44A4-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC44A4-001 ENSP00000229729 ENST00000229729	Q53GD3 [Direct mapping] Choline transporter-like protein 4 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005886 [plasma membrane] GO:0006644 [phospholipid metabolic process] GO:0006656 [phosphatidylcholine biosynthetic process] GO:0008292 [acetylcholine biosynthetic process] GO:0016021 [integral component of membrane] GO:0030307 [positive regulation of cell growth] GO:0044281 [small molecule metabolic process] GO:0046474 [glycerophospholipid biosynthetic process] GO:0055085 [transmembrane transport] GO:0061526 [acetylcholine secretion] GO:0070062 [extracellular exosome] Show all	710 aa 79.3 kDa	No	>9
SLC44A4-004 ENSP00000398901 ENST00000414427	H0Y5I3 [Direct mapping] Choline transporter-like protein 4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	411 aa 45.6 kDa	No	5
SLC44A4-201 ENSP00000364712 ENST00000375562	Q53GD3 [Direct mapping] Choline transporter-like protein 4 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005886 [plasma membrane] GO:0006644 [phospholipid metabolic process] GO:0006656 [phosphatidylcholine biosynthetic process] GO:0008292 [acetylcholine biosynthetic process] GO:0016021 [integral component of membrane] GO:0030307 [positive regulation of cell growth] GO:0044281 [small molecule metabolic process] GO:0046474 [glycerophospholipid biosynthetic process] GO:0055085 [transmembrane transport] GO:0061526 [acetylcholine secretion] GO:0070062 [extracellular exosome] Show all	668 aa 74.5 kDa	No	>9
SLC44A4-202 ENSP00000444109 ENST00000544672	Q53GD3 [Direct mapping] Choline transporter-like protein 4 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 9TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005886 [plasma membrane] GO:0006644 [phospholipid metabolic process] GO:0006656 [phosphatidylcholine biosynthetic process] GO:0008292 [acetylcholine biosynthetic process] GO:0016021 [integral component of membrane] GO:0030307 [positive regulation of cell growth] GO:0044281 [small molecule metabolic process] GO:0046474 [glycerophospholipid biosynthetic process] GO:0055085 [transmembrane transport] GO:0061526 [acetylcholine secretion] GO:0070062 [extracellular exosome] Show all	634 aa 70.8 kDa	No	9

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.