Cell atlas - HSPA1L - The Human Protein Atlas

GENERAL INFORMATION
Gene name	HSPA1L
Gene description	Heat shock 70kDa protein 1-like
Protein class	Cancer-related genes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to vesicles. In addition localized to the nucleoplasm. Caution: Based on antibodies targeting proteins from multiple genes.
RNA cell category	Cell line enhanced (HEK 293)
Protein evidence	Evidence at protein level
Main location	Localized to the Vesicles (uncertain)
Additional location	In addition localized to the Nucleoplasm (uncertain)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Uncertain based on 1 antibody. HPA052504
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HEK 293) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to vesicles. In addition localized to the nucleoplasm. Caution: Based on antibodies targeting proteins from multiple genes.

Main location

Vesicles (uncertain)

Additional location

Nucleoplasm (uncertain)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location	Single-cell variation
HPA052504	CACO-2	Vesicles
HPA052504	PC-3	Nucleoplasm	Spatial
HPA052504	PC-3	Vesicles
HPA052504	U-2 OS	Vesicles

GENE INFORMATION
Gene name	HSPA1L (HGNC Symbol)
Synonyms	HSP70-HOM, hum70t
Description	Heat shock 70kDa protein 1-like (HGNC Symbol)
Entrez gene summary	This gene encodes a 70kDa heat shock protein. In conjunction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which also encode isoforms of the 70kDa heat shock protein. [provided by RefSeq, Jul 2008]
Chromosome	6
Cytoband	p21.33
Chromosome location (bp)	31809619 - 31815065
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000204390 (version 83.38)
Entrez gene	3305
UniProt	P34931 (UniProt - Evidence at protein level)
neXtProt	NX_P34931
Antibodypedia	HSPA1L antibodies

PROTEIN BROWSER

HSPA1L-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HSPA1L-001 ENSP00000364805 ENST00000375654	P34931 [Direct mapping] Heat shock 70 kDa protein 1-like Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002199 [zona pellucida receptor complex] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005654 [nucleoplasm] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0005829 [cytosol] GO:0006986 [response to unfolded protein] GO:0007339 [binding of sperm to zona pellucida] GO:0008180 [COP9 signalosome] GO:0031072 [heat shock protein binding] GO:0031625 [ubiquitin protein ligase binding] GO:0034605 [cellular response to heat] GO:0042026 [protein refolding] GO:0044297 [cell body] GO:0051082 [unfolded protein binding] GO:0072562 [blood microparticle] GO:1900034 [regulation of cellular response to heat] GO:1903955 [positive regulation of protein targeting to mitochondrion] Show all	641 aa 70.4 kDa	No	0