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LSM2

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GENERAL INFORMATION

Gene name

 LSM2

Gene description

 LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the nucleus.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleus (supported)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA066718
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the nucleus.

Main location

 Nucleus (supported)

 

 

 
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Low
High
G1
S
G2
M
N/A

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Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA066718 MCF7 Nucleus
HPA066718 SK-MEL-30 Nucleus
HPA066718 U-2 OS Nucleus

GENE INFORMATION

Gene name

 LSM2 (HGNC Symbol)

Synonyms

 C6orf28, G7b, YBL026W

Description

 LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the LSm family of RNA-binding proteins. LSm proteins form stable heteromers that bind specifically to the 3'-terminal oligo(U) tract of U6 snRNA and may play a role in pre-mRNA splicing by mediating U4/U6 snRNP formation. Pseudogenes of this gene are located on the short arm of chromosomes 6 and 19. [provided by RefSeq, Nov 2011]

Chromosome

 6

Cytoband

 p21.33

Chromosome location (bp)

 31797396 - 31806984

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000204392 (version 83.38)

Entrez gene

 57819

UniProt

 Q9Y333 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y333

Antibodypedia

 LSM2 antibodies

PROTEIN BROWSER
LSM2-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
LSM2-001
ENSP00000364813
ENST00000375661
Q9Y333 [Direct mapping]
U6 snRNA-associated Sm-like protein LSm2
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000288 [nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0000932 [cytoplasmic mRNA processing body]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005688 [U6 snRNP]
GO:0005829 [cytosol]
GO:0006397 [mRNA processing]
GO:0008380 [RNA splicing]
GO:0010467 [gene expression]
GO:0017070 [U6 snRNA binding]
GO:0017160 [Ral GTPase binding]
GO:0019901 [protein kinase binding]
GO:0043928 [exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay]
GO:0044822 [poly(A) RNA binding]
GO:0046540 [U4/U6 x U5 tri-snRNP complex]
GO:0071011 [precatalytic spliceosome]
GO:0071013 [catalytic step 2 spliceosome]
GO:1990726 [Lsm1-7-Pat1 complex]
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 95 aa
10.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.