Fields »
ABOUT
HELP
BLOG
LSM2

GENERAL INFORMATION

Gene name

 LSM2

Gene description

 LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA066718
SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA066718

GENE INFORMATION

Gene name

 LSM2 (HGNC Symbol)

Synonyms

 C6orf28, G7b, YBL026W

Description

 LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the LSm family of RNA-binding proteins. LSm proteins form stable heteromers that bind specifically to the 3'-terminal oligo(U) tract of U6 snRNA and may play a role in pre-mRNA splicing by mediating U4/U6 snRNP formation. Pseudogenes of this gene are located on the short arm of chromosomes 6 and 19. [provided by RefSeq, Nov 2011]

Chromosome

 6

Cytoband

 p21.33

Chromosome location (bp)

 31797396 - 31806984

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000204392 (version 83.38)

Entrez gene

 57819

UniProt

 Q9Y333 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y333

Antibodypedia

 LSM2 antibodies

PROTEIN BROWSER
LSM2-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
LSM2-001
ENSP00000364813
ENST00000375661
Q9Y333 [Direct mapping]
U6 snRNA-associated Sm-like protein LSm2
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000288 [nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0000932 [cytoplasmic mRNA processing body]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005688 [U6 snRNP]
GO:0005829 [cytosol]
GO:0006397 [mRNA processing]
GO:0008380 [RNA splicing]
GO:0010467 [gene expression]
GO:0017070 [U6 snRNA binding]
GO:0017160 [Ral GTPase binding]
GO:0019901 [protein kinase binding]
GO:0043928 [exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay]
GO:0044822 [poly(A) RNA binding]
GO:0046540 [U4/U6 x U5 tri-snRNP complex]
GO:0071011 [precatalytic spliceosome]
GO:0071013 [catalytic step 2 spliceosome]
GO:1990726 [Lsm1-7-Pat1 complex]
Show all
 95 aa
10.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.