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MSH5

GENERAL INFORMATION

Gene name

 MSH5

Gene description

 MutS homolog 5

Protein class

 Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 8
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Mixed
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

DATA RELIABILITY

Reliability score

 Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 MSH5

Synonyms

Description

 MutS homolog 5 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the mutS family of proteins that are involved in DNA mismatch repair and meiotic recombination. This protein is similar to a Saccharomyces cerevisiae protein that participates in segregation fidelity and crossing-over events during meiosis. This protein plays a role in promoting ionizing radiation-induced apoptosis. This protein forms hetero-oligomers with another member of this family, mutS homolog 4. Polymorphisms in this gene have been linked to various human diseases, including IgA deficiency, common variable immunodeficiency, and premature ovarian failure. Alternative splicing results multiple transcript variants. Read-through transcription also exists between this gene and the downstream chromosome 6 open reading frame 26 (C6orf26) gene. [provided by RefSeq, Feb 2011]

Chromosome

 6

Cytoband

 p21.33

Chromosome location (bp)

 31739948 - 31762834

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000204410 (version 83.38)

Entrez gene

 4439

UniProt

 O43196 (UniProt - Evidence at protein level)

neXtProt

 NX_O43196

Antibodypedia

 MSH5 antibodies

PROTEIN BROWSER
MSH5-001
MSH5-002
MSH5-004
MSH5-005
MSH5-006
MSH5-008
MSH5-011
MSH5-018

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MSH5-001
ENSP00000364908
ENST00000375755
O43196 [Direct mapping]
MutS protein homolog 5
A0A024RCM1 [Target identity:100%; Query identity:100%]
MutS homolog 5 (E. coli), isoform CRA_e
Show all
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Show all
GO:0000228 [nuclear chromosome]
GO:0000795 [synaptonemal complex]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0006298 [mismatch repair]
GO:0007131 [reciprocal meiotic recombination]
GO:0008094 [DNA-dependent ATPase activity]
GO:0030983 [mismatched DNA binding]
GO:0045143 [homologous chromosome segregation]
GO:0051026 [chiasma assembly]
Show all
 834 aa
92.9 kDa 		No 0
MSH5-002
ENSP00000364903
ENST00000375750
O43196 [Direct mapping]
MutS protein homolog 5
A0A024RCM1 [Target identity:100%; Query identity:100%]
MutS homolog 5 (E. coli), isoform CRA_e
Show all
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Show all
GO:0000228 [nuclear chromosome]
GO:0000795 [synaptonemal complex]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0006298 [mismatch repair]
GO:0007131 [reciprocal meiotic recombination]
GO:0008094 [DNA-dependent ATPase activity]
GO:0030983 [mismatched DNA binding]
GO:0045143 [homologous chromosome segregation]
GO:0051026 [chiasma assembly]
Show all
 834 aa
92.9 kDa 		No 0
MSH5-004
ENSP00000364855
ENST00000375703
O43196 [Direct mapping]
MutS protein homolog 5
A0A024RCV6 [Target identity:100%; Query identity:100%]
MutS homolog 5 (E. coli), isoform CRA_f
Show all
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Show all
GO:0000228 [nuclear chromosome]
GO:0000795 [synaptonemal complex]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0006298 [mismatch repair]
GO:0007131 [reciprocal meiotic recombination]
GO:0008094 [DNA-dependent ATPase activity]
GO:0030983 [mismatched DNA binding]
GO:0045143 [homologous chromosome segregation]
GO:0051026 [chiasma assembly]
Show all
 835 aa
93 kDa 		No 0
MSH5-005
ENSP00000364892
ENST00000375740
O43196 [Direct mapping]
MutS protein homolog 5
Show all
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Show all
GO:0000228 [nuclear chromosome]
GO:0000795 [synaptonemal complex]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0006298 [mismatch repair]
GO:0007131 [reciprocal meiotic recombination]
GO:0008094 [DNA-dependent ATPase activity]
GO:0030983 [mismatched DNA binding]
GO:0045143 [homologous chromosome segregation]
GO:0051026 [chiasma assembly]
Show all
 822 aa
91.9 kDa 		No 0
MSH5-006
ENSP00000379194
ENST00000395853
A2ABF0 [Direct mapping]
MutS protein homolog 5; cDNA FLJ39914 fis, clone SPLEN2018732, highly similar to MutS protein homolog 5
Show all
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
Show all
GO:0000228 [nuclear chromosome]
GO:0000795 [synaptonemal complex]
GO:0005524 [ATP binding]
GO:0006298 [mismatch repair]
GO:0007131 [reciprocal meiotic recombination]
GO:0008094 [DNA-dependent ATPase activity]
GO:0030983 [mismatched DNA binding]
GO:0045143 [homologous chromosome segregation]
GO:0051026 [chiasma assembly]
Show all
 508 aa
56.1 kDa 		Yes 0
MSH5-008
ENSP00000402842
ENST00000425703
Q5SSR2 [Direct mapping]
MutS protein homolog 5
Show all
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0000228 [nuclear chromosome]
GO:0000795 [synaptonemal complex]
GO:0007131 [reciprocal meiotic recombination]
GO:0008094 [DNA-dependent ATPase activity]
GO:0030983 [mismatched DNA binding]
GO:0045143 [homologous chromosome segregation]
GO:0051026 [chiasma assembly]
Show all
 194 aa
21.5 kDa 		No 0
MSH5-011
ENSP00000394971
ENST00000450148
A2ABE9 [Direct mapping]
MutS protein homolog 5
Show all
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   SignalP predicted secreted proteins
Predicted intracellular proteins
Show all
GO:0000228 [nuclear chromosome]
GO:0000795 [synaptonemal complex]
GO:0005524 [ATP binding]
GO:0006298 [mismatch repair]
GO:0007131 [reciprocal meiotic recombination]
GO:0008094 [DNA-dependent ATPase activity]
GO:0030983 [mismatched DNA binding]
GO:0045143 [homologous chromosome segregation]
GO:0051026 [chiasma assembly]
Show all
 333 aa
38.1 kDa 		No 0
MSH5-018
ENSP00000406849
ENST00000429846
A2ABF1 [Direct mapping]
MutS protein homolog 5
Show all
Predicted intracellular proteins
Show all
GO:0000228 [nuclear chromosome]
GO:0000795 [synaptonemal complex]
GO:0005524 [ATP binding]
GO:0006298 [mismatch repair]
GO:0007131 [reciprocal meiotic recombination]
GO:0008094 [DNA-dependent ATPase activity]
GO:0030983 [mismatched DNA binding]
GO:0045143 [homologous chromosome segregation]
GO:0051026 [chiasma assembly]
Show all
 156 aa
16.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.