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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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ABHD16A
  • TISSUE

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PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

ABHD16A

Gene description

Abhydrolase domain containing 16A

Protein class

Predicted membrane proteins

Predicted localization

Membrane

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (BJ hTERT+ SV40 Large T+ RasG12V)
HPA (normal tissue):Tissue enhanced (gallbladder, testis, thyroid gland)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in blood vessel endothelial cells in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining in cells/structures not annotated, view images. Pending external verification.

Reliability score

Approved based on 1 antibody.
HPA058606
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PROGNOSTIC SUMMARY

Prognostic marker in endometrial cancer (unfavourable).
Endometrial cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA058606

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

A few colorectal cancers and rare cases of ovarian and urothelial cancer exhibited weak to moderate cytoplasmic positivity. Remaining cancers were negative.

GENE INFORMATION

Gene name

ABHD16A (HGNC Symbol)

Synonyms

BAT5, D6S82E, NG26

Description

Abhydrolase domain containing 16A (HGNC Symbol)

Entrez gene summary

A cluster of genes, BAT1-BAT5, has been localized in the vicinity of the genes for tumor necrosis factor alpha and tumor necrosis factor beta. These genes are all within the human major histocompatibility complex class III region. The protein encoded by this gene is thought to be involved in some aspects of immunity. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010]

Chromosome

6

Cytoband

p21.33

Chromosome location (bp)

31686949 - 31703444

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000204427 (version 83.38)

Entrez gene

7920

UniProt

O95870 (UniProt - Evidence at protein level)

neXtProt

NX_O95870

Antibodypedia

ABHD16A antibodies

PROTEIN BROWSER

ABHD16A-001
ABHD16A-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ABHD16A-001
ENSP00000379282
ENST00000395952
O95870 [Direct mapping]
Abhydrolase domain-containing protein 16A
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0008152 [metabolic process]
GO:0016021 [integral component of membrane]
GO:0016787 [hydrolase activity]
Show all
558 aa
63.2 kDa
No 2
ABHD16A-005
ENSP00000410347
ENST00000440843
O95870 [Direct mapping]
Abhydrolase domain-containing protein 16A
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0008152 [metabolic process]
GO:0016021 [integral component of membrane]
GO:0016787 [hydrolase activity]
Show all
525 aa
59.4 kDa
No 1

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