Expression of ABHD16A in cancer - Summary - The Human Protein Atlas

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ABHD16A

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ABHD16A
Gene description	Abhydrolase domain containing 16A
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	2
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (BJ hTERT+ SV40 Large T+ RasG12V)
HPA (normal tissue):	Tissue enhanced (gallbladder, testis, thyroid gland)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in blood vessel endothelial cells in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining in cells/structures not annotated, view images. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA058606
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (unfavourable).
Endometrial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA058606

GENE INFORMATION
Gene name	ABHD16A (HGNC Symbol)
Synonyms	BAT5, D6S82E, NG26
Description	Abhydrolase domain containing 16A (HGNC Symbol)
Entrez gene summary	A cluster of genes, BAT1-BAT5, has been localized in the vicinity of the genes for tumor necrosis factor alpha and tumor necrosis factor beta. These genes are all within the human major histocompatibility complex class III region. The protein encoded by this gene is thought to be involved in some aspects of immunity. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010]
Chromosome	6
Cytoband	p21.33
Chromosome location (bp)	31686949 - 31703444
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000204427 (version 83.38)
Entrez gene	7920
UniProt	O95870 (UniProt - Evidence at protein level)
neXtProt	NX_O95870
Antibodypedia	ABHD16A antibodies

PROTEIN BROWSER

ABHD16A-001	ABHD16A-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ABHD16A-001 ENSP00000379282 ENST00000395952	O95870 [Direct mapping] Abhydrolase domain-containing protein 16A Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] GO:0016787 [hydrolase activity] Show all	558 aa 63.2 kDa	No	2
ABHD16A-005 ENSP00000410347 ENST00000440843	O95870 [Direct mapping] Abhydrolase domain-containing protein 16A Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] GO:0016787 [hydrolase activity] Show all	525 aa 59.4 kDa	No	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.