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CSNK2B

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GENERAL INFORMATION

Gene name

 CSNK2B

Gene description

 Casein kinase 2, beta polypeptide

Protein class

 Cancer-related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Mixed

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 CSNK2B

Synonyms

Description

 Casein kinase 2, beta polypeptide (HGNC Symbol)

Entrez gene summary

 This gene encodes the beta subunit of casein kinase II, a ubiquitous protein kinase which regulates metabolic pathways, signal transduction, transcription, translation, and replication. The enzyme is composed of three subunits, alpha, alpha prime and beta, which form a tetrameric holoenzyme. The alpha and alpha prime subunits are catalytic, while the beta subunit serves regulatory functions. The enzyme localizes to the endoplasmic reticulum and the Golgi apparatus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]

Chromosome

 6

Cytoband

 p21.33

Chromosome location (bp)

 31665236 - 31670343

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000204435 (version 83.38)

Entrez gene

 1460

UniProt

 P67870 (UniProt - Evidence at protein level)

neXtProt

 NX_P67870

Antibodypedia

 CSNK2B antibodies

PROTEIN BROWSER
CSNK2B-001
CSNK2B-004
CSNK2B-008
CSNK2B-009

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CSNK2B-001
ENSP00000365042
ENST00000375882
P67870 [Direct mapping]
Casein kinase II subunit beta
N0E4C7 [Target identity:100%; Query identity:100%]
Casein kinase II subunit beta
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0003682 [chromatin binding]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005956 [protein kinase CK2 complex]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0007411 [axon guidance]
GO:0008134 [transcription factor binding]
GO:0008285 [negative regulation of cell proliferation]
GO:0010862 [positive regulation of pathway-restricted SMAD protein phosphorylation]
GO:0016055 [Wnt signaling pathway]
GO:0019887 [protein kinase regulator activity]
GO:0019904 [protein domain specific binding]
GO:0031519 [PcG protein complex]
GO:0032927 [positive regulation of activin receptor signaling pathway]
GO:0033211 [adiponectin-activated signaling pathway]
GO:0042802 [identical protein binding]
GO:0043537 [negative regulation of blood vessel endothelial cell migration]
GO:0043623 [cellular protein complex assembly]
GO:0045859 [regulation of protein kinase activity]
GO:0046872 [metal ion binding]
GO:0051101 [regulation of DNA binding]
GO:0061154 [endothelial tube morphogenesis]
GO:0070062 [extracellular exosome]
Show all
 215 aa
24.9 kDa 		No 0
CSNK2B-004
ENSP00000365046
ENST00000375885
Q5SRQ6 [Direct mapping]
Casein kinase II subunit beta
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005956 [protein kinase CK2 complex]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0019887 [protein kinase regulator activity]
GO:0045859 [regulation of protein kinase activity]
Show all
 234 aa
26.9 kDa 		No 0
CSNK2B-008
ENSP00000365025
ENST00000375865
P67870 [Direct mapping]
Casein kinase II subunit beta
N0E4C7 [Target identity:100%; Query identity:100%]
Casein kinase II subunit beta
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0003682 [chromatin binding]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005956 [protein kinase CK2 complex]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0007411 [axon guidance]
GO:0008134 [transcription factor binding]
GO:0008285 [negative regulation of cell proliferation]
GO:0010862 [positive regulation of pathway-restricted SMAD protein phosphorylation]
GO:0016055 [Wnt signaling pathway]
GO:0019887 [protein kinase regulator activity]
GO:0019904 [protein domain specific binding]
GO:0031519 [PcG protein complex]
GO:0032927 [positive regulation of activin receptor signaling pathway]
GO:0033211 [adiponectin-activated signaling pathway]
GO:0042802 [identical protein binding]
GO:0043537 [negative regulation of blood vessel endothelial cell migration]
GO:0043623 [cellular protein complex assembly]
GO:0045859 [regulation of protein kinase activity]
GO:0046872 [metal ion binding]
GO:0051101 [regulation of DNA binding]
GO:0061154 [endothelial tube morphogenesis]
GO:0070062 [extracellular exosome]
Show all
 215 aa
24.9 kDa 		No 0
CSNK2B-009
ENSP00000365026
ENST00000375866
P67870 [Direct mapping]
Casein kinase II subunit beta
N0E4C7 [Target identity:100%; Query identity:100%]
Casein kinase II subunit beta
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0003682 [chromatin binding]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005956 [protein kinase CK2 complex]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0007411 [axon guidance]
GO:0008134 [transcription factor binding]
GO:0008285 [negative regulation of cell proliferation]
GO:0010862 [positive regulation of pathway-restricted SMAD protein phosphorylation]
GO:0016055 [Wnt signaling pathway]
GO:0019887 [protein kinase regulator activity]
GO:0019904 [protein domain specific binding]
GO:0031519 [PcG protein complex]
GO:0032927 [positive regulation of activin receptor signaling pathway]
GO:0033211 [adiponectin-activated signaling pathway]
GO:0042802 [identical protein binding]
GO:0043537 [negative regulation of blood vessel endothelial cell migration]
GO:0043623 [cellular protein complex assembly]
GO:0045859 [regulation of protein kinase activity]
GO:0046872 [metal ion binding]
GO:0051101 [regulation of DNA binding]
GO:0061154 [endothelial tube morphogenesis]
GO:0070062 [extracellular exosome]
Show all
 215 aa
24.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.