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APOM

GENERAL INFORMATION

Gene name

 APOM

Gene description

 Apolipoprotein M

Protein class

 Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enriched (liver cancer)
HPA (cell line):Mixed
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Extracellular deposits and cytoplasmic expression in several different tissue types.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.

Reliability score

 Approved based on 2 antibodies.
HPA051006 , CAB034086
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enriched (liver cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA051006
CAB034086

GENE INFORMATION

Gene name

 APOM (HGNC Symbol)

Synonyms

 ApoM, G3a, NG20

Description

 Apolipoprotein M (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is an apolipoprotein and member of the lipocalin protein family. It is found associated with high density lipoproteins and to a lesser extent with low density lipoproteins and triglyceride-rich lipoproteins. The encoded protein is secreted through the plasma membrane but remains membrane-bound, where it is involved in lipid transport. Alternate splicing results in both coding and non-coding variants of this gene. [provided by RefSeq, Jan 2012]

Chromosome

 6

Cytoband

 p21.33

Chromosome location (bp)

 31652416 - 31658210

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000204444 (version 83.38)

Entrez gene

 55937

UniProt

 O95445 (UniProt - Evidence at protein level)

neXtProt

 NX_O95445

Antibodypedia

 APOM antibodies

PROTEIN BROWSER
APOM-001
APOM-002
APOM-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
APOM-001
ENSP00000365081
ENST00000375916
O95445 [Direct mapping]
Apolipoprotein M
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   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001523 [retinoid metabolic process]
GO:0005319 [lipid transporter activity]
GO:0005543 [phospholipid binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005887 [integral component of plasma membrane]
GO:0007603 [phototransduction, visible light]
GO:0009749 [response to glucose]
GO:0016209 [antioxidant activity]
GO:0033344 [cholesterol efflux]
GO:0034361 [very-low-density lipoprotein particle]
GO:0034362 [low-density lipoprotein particle]
GO:0034364 [high-density lipoprotein particle]
GO:0034365 [discoidal high-density lipoprotein particle]
GO:0034366 [spherical high-density lipoprotein particle]
GO:0034375 [high-density lipoprotein particle remodeling]
GO:0034380 [high-density lipoprotein particle assembly]
GO:0034384 [high-density lipoprotein particle clearance]
GO:0034445 [negative regulation of plasma lipoprotein particle oxidation]
GO:0042157 [lipoprotein metabolic process]
GO:0042632 [cholesterol homeostasis]
GO:0043691 [reverse cholesterol transport]
GO:0070062 [extracellular exosome]
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 188 aa
21.3 kDa 		Yes 0
APOM-002
ENSP00000365085
ENST00000375920
O95445 [Direct mapping]
Apolipoprotein M
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001523 [retinoid metabolic process]
GO:0005319 [lipid transporter activity]
GO:0005543 [phospholipid binding]
GO:0005576 [extracellular region]
GO:0005887 [integral component of plasma membrane]
GO:0007603 [phototransduction, visible light]
GO:0016209 [antioxidant activity]
GO:0033344 [cholesterol efflux]
GO:0034361 [very-low-density lipoprotein particle]
GO:0034362 [low-density lipoprotein particle]
GO:0034364 [high-density lipoprotein particle]
GO:0034365 [discoidal high-density lipoprotein particle]
GO:0034366 [spherical high-density lipoprotein particle]
GO:0034375 [high-density lipoprotein particle remodeling]
GO:0034380 [high-density lipoprotein particle assembly]
GO:0034384 [high-density lipoprotein particle clearance]
GO:0034445 [negative regulation of plasma lipoprotein particle oxidation]
GO:0042632 [cholesterol homeostasis]
GO:0043691 [reverse cholesterol transport]
GO:0070062 [extracellular exosome]
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 116 aa
13.1 kDa 		No 0
APOM-003
ENSP00000365083
ENST00000375918
Q5SRP5 [Direct mapping]
Apolipoprotein M
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 129 aa
14.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.