Expression of MCCD1 in cancer - Summary - The Human Protein Atlas

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MCCD1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	MCCD1
Gene description	Mitochondrial coiled-coil domain 1
Protein class	Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (liver cancer, renal cancer)
HPA (cell line):	Not detected
HPA (normal tissue):	Tissue enriched (kidney)

Protein evidence

Evidence at transcript level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA046948
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (liver cancer, renal cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA046948

GENE INFORMATION
Gene name	MCCD1
Synonyms
Description	Mitochondrial coiled-coil domain 1 (HGNC Symbol)
Entrez gene summary
Chromosome	6
Cytoband	p21.33
Chromosome location (bp)	31528717 - 31530232
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000204511 (version 83.38)
Entrez gene	401250
UniProt	P59942 (UniProt - Evidence at transcript level)
neXtProt	NX_P59942
Antibodypedia	MCCD1 antibodies

PROTEIN BROWSER

MCCD1-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MCCD1-001 ENSP00000365362 ENST00000376191	P59942 [Direct mapping] Mitochondrial coiled-coil domain protein 1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005739 [mitochondrion] Show all	119 aa 13.3 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.