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RNA cell line category: Cell line enhanced (EFO-21, A-431, U-266/70, RPTEC TERT1, U-266/84)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.
Cell lines sorted after biological source for establishment.
Cell lines sorted after the cell line category according to Cellosaurus.
Cell lines sorted on descending RNA expression.
Cell lines sorted alphabetically.
GENE INFORMATION
Gene name
HLA-C (HGNC Symbol)
Synonyms
D6S204, HLA-JY3, PSORS1
Description
Major histocompatibility complex, class I, C (HGNC Symbol)
Entrez gene summary
HLA-C belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Over one hundred HLA-C alleles have been described [provided by RefSeq, Jul 2008]
P10321 [Direct mapping] HLA class I histocompatibility antigen, Cw-7 alpha chain Q6R739 [Target identity:100%; Query identity:100%] HLA class I antigen; MHC class I antigen
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Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000139 [Golgi membrane] GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent] GO:0002480 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent] GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0006955 [immune response] GO:0009986 [cell surface] GO:0012507 [ER to Golgi transport vesicle membrane] GO:0016032 [viral process] GO:0019221 [cytokine-mediated signaling pathway] GO:0019882 [antigen processing and presentation] GO:0030670 [phagocytic vesicle membrane] GO:0031901 [early endosome membrane] GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I] GO:0042605 [peptide antigen binding] GO:0042612 [MHC class I protein complex] GO:0050776 [regulation of immune response] GO:0060333 [interferon-gamma-mediated signaling pathway] GO:0060337 [type I interferon signaling pathway] GO:0070062 [extracellular exosome] GO:0071556 [integral component of lumenal side of endoplasmic reticulum membrane]
GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] GO:0005515 [protein binding] GO:0006955 [immune response] GO:0016021 [integral component of membrane] GO:0019882 [antigen processing and presentation] GO:0042605 [peptide antigen binding] GO:0042612 [MHC class I protein complex]
