Expression of PSORS1C2 in cancer - Summary - The Human Protein Atlas

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PSORS1C2

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PSORS1C2
Gene description	Psoriasis susceptibility 1 candidate 2
Protein class	Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (urothelial cancer)
HPA (cell line):	Not detected
HPA (normal tissue):	Tissue enriched (skin)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in stratum granulosum of skin.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.
Reliability score	Supported based on 1 antibody. HPA061228
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (urothelial cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA061228

GENE INFORMATION
Gene name	PSORS1C2 (HGNC Symbol)
Synonyms	C6orf17, SPR1
Description	Psoriasis susceptibility 1 candidate 2 (HGNC Symbol)
Entrez gene summary
Chromosome	6
Cytoband	p21.33
Chromosome location (bp)	31137536 - 31139350
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000204538 (version 83.38)
Entrez gene	170680
UniProt	Q9UIG4 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9UIG4
Antibodypedia	PSORS1C2 antibodies

PROTEIN BROWSER

PSORS1C2-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PSORS1C2-001 ENSP00000259845 ENST00000259845	Q9UIG4 [Direct mapping] Psoriasis susceptibility 1 candidate gene 2 protein Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0003674 [molecular_function] GO:0005575 [cellular_component] GO:0005576 [extracellular region] GO:0008150 [biological_process] Show all	136 aa 15.1 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.