Expression of CDSN in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	CDSN
Gene description	Corneodesmosin
Protein class	Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Group enriched (head and neck cancer, melanoma)
HPA (cell line):	Cell line enriched (A-431)
HPA (normal tissue):	Tissue enriched (skin)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and membranous expression in squamous epithelia of skin, vagina and oral mucosa.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA044730 , HPA054184
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Group enriched (head and neck cancer, melanoma)

PROTEIN EXPRESSION

STAINING SUMMARY

HPA044730	HPA054184

GENE INFORMATION
Gene name	CDSN (HGNC Symbol)
Synonyms	D6S586E
Description	Corneodesmosin (HGNC Symbol)
Entrez gene summary	This gene encodes a protein found in corneodesmosomes, which localize to human epidermis and other cornified squamous epithelia. The encoded protein undergoes a series of cleavages during corneocyte maturation. This gene is highly polymorphic in human populations, and variation has been associated with skin diseases such as psoriasis, hypotrichosis and peeling skin syndrome. The gene is located in the major histocompatibility complex (MHC) class I region on chromosome 6. [provided by RefSeq, Dec 2014]
Chromosome	6
Cytoband	p21.33
Chromosome location (bp)	31115090 - 31120446
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000204539 (version 83.38)
Entrez gene	1041
UniProt
neXtProt
Antibodypedia	CDSN antibodies

PROTEIN BROWSER

CDSN-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CDSN-001 ENSP00000365465 ENST00000376288	G8JLG2 [Direct mapping] Corneodesmosin Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0043589 [skin morphogenesis] Show all	529 aa 51.6 kDa	Yes	0