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PPP1R10

GENERAL INFORMATION

Gene name

 PPP1R10

Gene description

 Protein phosphatase 1, regulatory subunit 10

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA047248 , HPA056756 , CAB025501
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (favourable) and cervical cancer (favourable).
Pancreatic cancer p<0.001
Cervical cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA047248
HPA056756
CAB025501

GENE INFORMATION

Gene name

 PPP1R10 (HGNC Symbol)

Synonyms

 CAT53, FB19, p99, PNUTS

Description

 Protein phosphatase 1, regulatory subunit 10 (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein phosphatase 1 binding protein. The encoded protein plays a role in many cellular processes including cell cycle progression, DNA repair and apoptosis by regulating the activity of protein phosphatase 1. This gene lies within the major histocompatibility complex class I region on chromosome 6, and alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012]

Chromosome

 6

Cytoband

 p21.33

Chromosome location (bp)

 30600400 - 30618612

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000204569 (version 83.38)

Entrez gene

 5514

UniProt

 Q96QC0 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96QC0

Antibodypedia

 PPP1R10 antibodies

PROTEIN BROWSER
PPP1R10-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PPP1R10-001
ENSP00000365694
ENST00000376511
Q96QC0 [Direct mapping]
Serine/threonine-protein phosphatase 1 regulatory subunit 10
Q2L6I0 [Target identity:100%; Query identity:100%]
FB19 protein; Protein phosphatase 1, regulatory (Inhibitor) subunit 10; Protein phosphatase 1, regulatory subunit 10
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000785 [chromatin]
GO:0003677 [DNA binding]
GO:0004864 [protein phosphatase inhibitor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006606 [protein import into nucleus]
GO:0043086 [negative regulation of catalytic activity]
GO:0044822 [poly(A) RNA binding]
GO:0046872 [metal ion binding]
GO:0072357 [PTW/PP1 phosphatase complex]
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 940 aa
99.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.