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Major histocompatibility complex, class I, G (HGNC Symbol)
Entrez gene summary
HLA-G belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-G is expressed on fetal derived placental cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exon 6 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008]
P17693 [Direct mapping] HLA class I histocompatibility antigen, alpha chain G Q6DU14 [Target identity:100%; Query identity:100%] HLA-G histocompatibility antigen, class I, G, isoform CRA_a; MHC class I antigen; MHC class Ib antigen; Truncated MHC class I antigen
GO:0000139 [Golgi membrane] GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent] GO:0002480 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent] GO:0002645 [positive regulation of tolerance induction] GO:0002666 [positive regulation of T cell tolerance induction] GO:0002767 [immune response-inhibiting cell surface receptor signaling pathway] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006955 [immune response] GO:0006968 [cellular defense response] GO:0012507 [ER to Golgi transport vesicle membrane] GO:0016020 [membrane] GO:0019221 [cytokine-mediated signaling pathway] GO:0030670 [phagocytic vesicle membrane] GO:0031901 [early endosome membrane] GO:0032735 [positive regulation of interleukin-12 production] GO:0042130 [negative regulation of T cell proliferation] GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I] GO:0042605 [peptide antigen binding] GO:0042612 [MHC class I protein complex] GO:0042803 [protein homodimerization activity] GO:0045591 [positive regulation of regulatory T cell differentiation] GO:0050776 [regulation of immune response] GO:0050777 [negative regulation of immune response] GO:0060333 [interferon-gamma-mediated signaling pathway] GO:0060337 [type I interferon signaling pathway] GO:0071556 [integral component of lumenal side of endoplasmic reticulum membrane] GO:2001199 [negative regulation of dendritic cell differentiation]
GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] GO:0005515 [protein binding] GO:0006955 [immune response] GO:0016021 [integral component of membrane] GO:0042605 [peptide antigen binding] GO:0042612 [MHC class I protein complex]
P17693 [Direct mapping] HLA class I histocompatibility antigen, alpha chain G Q6DU14 [Target identity:100%; Query identity:100%] HLA-G histocompatibility antigen, class I, G, isoform CRA_a; MHC class I antigen; MHC class Ib antigen; Truncated MHC class I antigen
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Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014)
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GO:0000139 [Golgi membrane] GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent] GO:0002480 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent] GO:0002645 [positive regulation of tolerance induction] GO:0002666 [positive regulation of T cell tolerance induction] GO:0002767 [immune response-inhibiting cell surface receptor signaling pathway] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006955 [immune response] GO:0006968 [cellular defense response] GO:0012507 [ER to Golgi transport vesicle membrane] GO:0016020 [membrane] GO:0019221 [cytokine-mediated signaling pathway] GO:0030670 [phagocytic vesicle membrane] GO:0031901 [early endosome membrane] GO:0032735 [positive regulation of interleukin-12 production] GO:0042130 [negative regulation of T cell proliferation] GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I] GO:0042605 [peptide antigen binding] GO:0042612 [MHC class I protein complex] GO:0042803 [protein homodimerization activity] GO:0045591 [positive regulation of regulatory T cell differentiation] GO:0050776 [regulation of immune response] GO:0050777 [negative regulation of immune response] GO:0060333 [interferon-gamma-mediated signaling pathway] GO:0060337 [type I interferon signaling pathway] GO:0071556 [integral component of lumenal side of endoplasmic reticulum membrane] GO:2001199 [negative regulation of dendritic cell differentiation]
