Expression of ASPDH in cancer - Summary

GENERAL INFORMATION
Gene name	ASPDH
Gene description	Aspartate dehydrogenase domain containing
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (liver cancer)
HPA (cell line):	Cell line enhanced (HEK93, MOLT-4, SH-SY5Y)
HPA (normal tissue):	Group enriched (cerebral cortex, duodenum, kidney, liver)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and nuclear expression in several different tissues types, most abundant in hepatocytes of liver and renal tubules of kidney.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 2 antibodies. HPA042631 , HPA042654
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (liver cancer)

PROTEIN EXPRESSION

STAINING SUMMARY

HPA042631	HPA042654

GENE INFORMATION
Gene name	ASPDH
Synonyms
Description	Aspartate dehydrogenase domain containing (HGNC Symbol)
Entrez gene summary
Chromosome	19
Cytoband	q13.33
Chromosome location (bp)	50511600 - 50514690
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000204653 (version 83.38)
Entrez gene	554235
UniProt	A6ND91 (UniProt - Evidence at protein level)
neXtProt	NX_A6ND91
Antibodypedia	ASPDH antibodies

PROTEIN BROWSER

ASPDH-001	ASPDH-002	ASPDH-006	ASPDH-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ASPDH-001 ENSP00000366114 ENST00000376916	A6ND91 [Direct mapping] Putative L-aspartate dehydrogenase Show all	Enzymes ENZYME proteins Oxidoreductases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0006742 [NADP catabolic process] GO:0009435 [NAD biosynthetic process] GO:0016491 [oxidoreductase activity] GO:0019363 [pyridine nucleotide biosynthetic process] GO:0033735 [aspartate dehydrogenase activity] GO:0050661 [NADP binding] GO:0055114 [oxidation-reduction process] Show all	178 aa 18.7 kDa	No	0
ASPDH-002 ENSP00000373860 ENST00000389208	A6ND91 [Direct mapping] Putative L-aspartate dehydrogenase Show all	Enzymes ENZYME proteins Oxidoreductases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0006742 [NADP catabolic process] GO:0009435 [NAD biosynthetic process] GO:0016491 [oxidoreductase activity] GO:0019363 [pyridine nucleotide biosynthetic process] GO:0033735 [aspartate dehydrogenase activity] GO:0050661 [NADP binding] GO:0055114 [oxidation-reduction process] Show all	283 aa 29.9 kDa	No	0
ASPDH-006 ENSP00000470360 ENST00000601207	M0QZ80 [Direct mapping] Putative L-aspartate dehydrogenase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006742 [NADP catabolic process] GO:0016491 [oxidoreductase activity] GO:0019363 [pyridine nucleotide biosynthetic process] GO:0055114 [oxidation-reduction process] Show all	134 aa 13.8 kDa	No	0
ASPDH-007 ENSP00000469754 ENST00000598657	M0QYD4 [Direct mapping] Putative L-aspartate dehydrogenase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016491 [oxidoreductase activity] GO:0050661 [NADP binding] GO:0055114 [oxidation-reduction process] Show all	51 aa 5.5 kDa	No	0