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Expression mainly in lymphoid systems and immune cells in several tissues.
DATA RELIABILITY
Data reliability description
Secreted protein, tissue location of RNA and protein might differ and correlation is complex. External characterization data supports antibody staining pattern while RNA data does not.
IL31, which is made principally by activated Th2-type T cells, interacts with a heterodimeric receptor consisting of IL31RA (MIM 609510) and OSMR (MIM 601743) that is constitutively expressed on epithelial cells and keratinocytes. IL31 may be involved in the promotion of allergic skin disorders and in regulating other allergic diseases, such as asthma (Dillon et al., 2004 [PubMed 15184896]).[supplied by OMIM, Mar 2008]