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AKT1S1

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GENERAL INFORMATION

Gene name

 AKT1S1

Gene description

 AKT1 substrate 1 (proline-rich)

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 8
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the cytosol.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Cytosol (supported)

Mouse

 Localized to the Cytosol in mouse cells.

DATA RELIABILITY

Reliability score

 Supported based on 2 antibodies.
CAB021903 , HPA043590
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ASSAYS
RNA expression
Human cells
Mouse cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the cytosol.

Main location

 Cytosol (supported)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
CAB021903 A-431 No staining    
CAB021903 U-2 OS Cytosol
CAB021903 U-251 MG No staining    
HPA043590 HEK 293 Cytosol
HPA043590 PC-3 Cytosol
HPA043590 U-2 OS Cytosol

MOUSE CELLS

Main location

 Cytosol

Mouse gene

 ENSMUSG00000011096 (version 83)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location
HPA043590 NIH 3T3 Cytosol

GENE INFORMATION

Gene name

 AKT1S1 (HGNC Symbol)

Synonyms

 Lobe, MGC2865, PRAS40

Description

 AKT1 substrate 1 (proline-rich) (HGNC Symbol)

Entrez gene summary

 AKT1S1 is a proline-rich substrate of AKT (MIM 164730) that binds 14-3-3 protein (see YWHAH, MIM 113508) when phosphorylated (Kovacina et al., 2003 [PubMed 12524439]).[supplied by OMIM, Mar 2008]

Chromosome

 19

Cytoband

 q13.33

Chromosome location (bp)

 49869033 - 49878459

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000204673 (version 83.38)

Entrez gene

 84335

UniProt

 Q96B36 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96B36

Antibodypedia

 AKT1S1 antibodies

PROTEIN BROWSER
AKT1S1-001
AKT1S1-002
AKT1S1-003
AKT1S1-004
AKT1S1-005
AKT1S1-006
AKT1S1-011
AKT1S1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AKT1S1-001
ENSP00000341698
ENST00000344175
Q96B36 [Direct mapping]
Proline-rich AKT1 substrate 1
A0A024QZF6 [Target identity:100%; Query identity:100%]
AKT1 substrate 1 (Proline-rich), isoform CRA_a
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006469 [negative regulation of protein kinase activity]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0031931 [TORC1 complex]
GO:0032007 [negative regulation of TOR signaling]
GO:0034605 [cellular response to heat]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0043523 [regulation of neuron apoptotic process]
GO:0045087 [innate immune response]
GO:0045792 [negative regulation of cell size]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:1900034 [regulation of cellular response to heat]
Show all
 256 aa
27.4 kDa 		No 0
AKT1S1-002
ENSP00000375711
ENST00000391835
Q96B36 [Direct mapping]
Proline-rich AKT1 substrate 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006469 [negative regulation of protein kinase activity]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0031931 [TORC1 complex]
GO:0032007 [negative regulation of TOR signaling]
GO:0034605 [cellular response to heat]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0043234 [protein complex]
GO:0043523 [regulation of neuron apoptotic process]
GO:0045087 [innate immune response]
GO:0045792 [negative regulation of cell size]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:1900034 [regulation of cellular response to heat]
Show all
 276 aa
29.3 kDa 		No 0
AKT1S1-003
ENSP00000375708
ENST00000391832
Q96B36 [Direct mapping]
Proline-rich AKT1 substrate 1
A0A024QZF6 [Target identity:100%; Query identity:100%]
AKT1 substrate 1 (Proline-rich), isoform CRA_a
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006469 [negative regulation of protein kinase activity]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0031931 [TORC1 complex]
GO:0032007 [negative regulation of TOR signaling]
GO:0034605 [cellular response to heat]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0043523 [regulation of neuron apoptotic process]
GO:0045087 [innate immune response]
GO:0045792 [negative regulation of cell size]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:1900034 [regulation of cellular response to heat]
Show all
 256 aa
27.4 kDa 		No 0
AKT1S1-004
ENSP00000375707
ENST00000391831
Q96B36 [Direct mapping]
Proline-rich AKT1 substrate 1
A0A024QZF6 [Target identity:100%; Query identity:100%]
AKT1 substrate 1 (Proline-rich), isoform CRA_a
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006469 [negative regulation of protein kinase activity]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0031931 [TORC1 complex]
GO:0032007 [negative regulation of TOR signaling]
GO:0034605 [cellular response to heat]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0043523 [regulation of neuron apoptotic process]
GO:0045087 [innate immune response]
GO:0045792 [negative regulation of cell size]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:1900034 [regulation of cellular response to heat]
Show all
 256 aa
27.4 kDa 		No 0
AKT1S1-005
ENSP00000375709
ENST00000391833
Q96B36 [Direct mapping]
Proline-rich AKT1 substrate 1
A0A024QZF6 [Target identity:100%; Query identity:100%]
AKT1 substrate 1 (Proline-rich), isoform CRA_a
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006469 [negative regulation of protein kinase activity]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0031931 [TORC1 complex]
GO:0032007 [negative regulation of TOR signaling]
GO:0034605 [cellular response to heat]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0043523 [regulation of neuron apoptotic process]
GO:0045087 [innate immune response]
GO:0045792 [negative regulation of cell size]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:1900034 [regulation of cellular response to heat]
Show all
 256 aa
27.4 kDa 		No 0
AKT1S1-006
ENSP00000375706
ENST00000391830
H9KV91 [Direct mapping]
Proline-rich AKT1 substrate 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0032007 [negative regulation of TOR signaling]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
Show all
 108 aa
11.3 kDa 		No 0
AKT1S1-011
ENSP00000472839
ENST00000599525
M0R2V8 [Direct mapping]
Proline-rich AKT1 substrate 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 33 aa
3.6 kDa 		No 0
AKT1S1-201
ENSP00000375710
ENST00000391834
Q96B36 [Direct mapping]
Proline-rich AKT1 substrate 1
A0A024QZF6 [Target identity:100%; Query identity:100%]
AKT1 substrate 1 (Proline-rich), isoform CRA_a
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006469 [negative regulation of protein kinase activity]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0031931 [TORC1 complex]
GO:0032007 [negative regulation of TOR signaling]
GO:0034605 [cellular response to heat]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0043523 [regulation of neuron apoptotic process]
GO:0045087 [innate immune response]
GO:0045792 [negative regulation of cell size]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:1900034 [regulation of cellular response to heat]
Show all
 256 aa
27.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.