Expression of GABBR1 in cancer - Summary - The Human Protein Atlas

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GABBR1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	GABBR1
Gene description	Gamma-aminobutyric acid (GABA) B receptor, 1
Protein class	FDA approved drug targets G-protein coupled receptors Plasma proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Tissue enhanced (cerebral cortex)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues, most abundant in CNS.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
Reliability score	Uncertain based on 1 antibody. HPA050483
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and pancreatic cancer (favourable).
Renal cancer p<0.001 Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA050483

GENE INFORMATION
Gene name	GABBR1 (HGNC Symbol)
Synonyms	GPRC3A, hGB1a
Description	Gamma-aminobutyric acid (GABA) B receptor, 1 (HGNC Symbol)
Entrez gene summary	Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the mammalian central nervous system. GABA exerts its effects through ionotropic [GABA(A/C)] receptors, to produce fast synaptic inhibition, and metabotropic [GABA(B)] receptors, to produce slow, prolonged inhibitory signals. The GABA(B) receptor consists of a heterodimer of two related 7-transmembrane receptors, GABA(B) receptor 1 and GABA(B) receptor 2. The GABA(B) receptor 1 gene is mapped to chromosome 6p21.3 within the HLA class I region close to the HLA-F gene. Susceptibility loci for multiple sclerosis, epilepsy, and schizophrenia have also been mapped in this region. Alternative splicing of this gene generates multiple transcript variants. [provided by RefSeq, Jun 2009]
Chromosome	6
Cytoband	p22.1
Chromosome location (bp)	29555629 - 29633976
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000204681 (version 83.38)
Entrez gene	2550
UniProt	Q9UBS5 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UBS5
Antibodypedia	GABBR1 antibodies

PROTEIN BROWSER

GABBR1-001	GABBR1-002	GABBR1-003	GABBR1-004	GABBR1-015	GABBR1-016	GABBR1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GABBR1-001 ENSP00000366233 ENST00000377034	Q9UBS5 [Direct mapping] Gamma-aminobutyric acid type B receptor subunit 1 Show all	Family 3 (C) receptors G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Plasma proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Show all	GO:0001649 [osteoblast differentiation] GO:0004930 [G-protein coupled receptor activity] GO:0004965 [G-protein coupled GABA receptor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0005789 [endoplasmic reticulum membrane] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007193 [adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway] GO:0007194 [negative regulation of adenylate cyclase activity] GO:0007214 [gamma-aminobutyric acid signaling pathway] GO:0007268 [synaptic transmission] GO:0008021 [synaptic vesicle] GO:0008134 [transcription factor binding] GO:0008285 [negative regulation of cell proliferation] GO:0014048 [regulation of glutamate secretion] GO:0014049 [positive regulation of glutamate secretion] GO:0014053 [negative regulation of gamma-aminobutyric acid secretion] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030054 [cell junction] GO:0030425 [dendrite] GO:0030673 [axolemma] GO:0030817 [regulation of cAMP biosynthetic process] GO:0031966 [mitochondrial membrane] GO:0032811 [negative regulation of epinephrine secretion] GO:0033602 [negative regulation of dopamine secretion] GO:0035094 [response to nicotine] GO:0038037 [G-protein coupled receptor dimeric complex] GO:0038039 [G-protein coupled receptor heterodimeric complex] GO:0042734 [presynaptic membrane] GO:0043005 [neuron projection] GO:0043025 [neuronal cell body] GO:0043197 [dendritic spine] GO:0043198 [dendritic shaft] GO:0043231 [intracellular membrane-bounded organelle] GO:0045121 [membrane raft] GO:0045211 [postsynaptic membrane] GO:0045471 [response to ethanol] GO:0050805 [negative regulation of synaptic transmission] GO:0060124 [positive regulation of growth hormone secretion] Show all	961 aa 108.3 kDa	Yes	7
GABBR1-002 ENSP00000348248 ENST00000355973	Q9UBS5 [Direct mapping] Gamma-aminobutyric acid type B receptor subunit 1 Q5SUJ9 [Target identity:100%; Query identity:100%] Gamma-aminobutyric acid (GABA) B receptor, 1, isoform CRA_h; cDNA FLJ77697, highly similar to Homo sapiens gamma-aminobutyric acid (GABA) B receptor, 1 (GABBR1), transcript variant 2, mRNA; cDNA, FLJ92613, Homo sapiens gamma-aminobutyric acid (GABA) B receptor, 1 (GABBR1),transcript variant 2, mRNA Show all	Family 3 (C) receptors G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Plasma proteins FDA approved drug targets Small molecule drugs Show all	GO:0004930 [G-protein coupled receptor activity] GO:0004965 [G-protein coupled GABA receptor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007193 [adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway] GO:0007194 [negative regulation of adenylate cyclase activity] GO:0007214 [gamma-aminobutyric acid signaling pathway] GO:0007268 [synaptic transmission] GO:0016021 [integral component of membrane] GO:0030054 [cell junction] GO:0030425 [dendrite] GO:0038039 [G-protein coupled receptor heterodimeric complex] GO:0045211 [postsynaptic membrane] Show all	844 aa 95.1 kDa	Yes	7
GABBR1-003 ENSP00000366215 ENST00000377016	Q9UBS5 [Direct mapping] Gamma-aminobutyric acid type B receptor subunit 1 Show all	Family 3 (C) receptors G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Plasma proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Show all	GO:0004930 [G-protein coupled receptor activity] GO:0004965 [G-protein coupled GABA receptor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007193 [adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway] GO:0007194 [negative regulation of adenylate cyclase activity] GO:0007214 [gamma-aminobutyric acid signaling pathway] GO:0007268 [synaptic transmission] GO:0016021 [integral component of membrane] GO:0030054 [cell junction] GO:0030425 [dendrite] GO:0038039 [G-protein coupled receptor heterodimeric complex] GO:0045211 [postsynaptic membrane] Show all	899 aa 101.5 kDa	Yes	7
GABBR1-004 ENSP00000366211 ENST00000377012	Q9UBS5 [Direct mapping] Gamma-aminobutyric acid type B receptor subunit 1 Q5SUJ9 [Target identity:100%; Query identity:100%] Gamma-aminobutyric acid (GABA) B receptor, 1, isoform CRA_h; cDNA FLJ77697, highly similar to Homo sapiens gamma-aminobutyric acid (GABA) B receptor, 1 (GABBR1), transcript variant 2, mRNA; cDNA, FLJ92613, Homo sapiens gamma-aminobutyric acid (GABA) B receptor, 1 (GABBR1),transcript variant 2, mRNA Show all	Family 3 (C) receptors G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Plasma proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Show all	GO:0004930 [G-protein coupled receptor activity] GO:0004965 [G-protein coupled GABA receptor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007193 [adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway] GO:0007194 [negative regulation of adenylate cyclase activity] GO:0007214 [gamma-aminobutyric acid signaling pathway] GO:0007268 [synaptic transmission] GO:0016021 [integral component of membrane] GO:0030054 [cell junction] GO:0030425 [dendrite] GO:0038039 [G-protein coupled receptor heterodimeric complex] GO:0045211 [postsynaptic membrane] Show all	844 aa 95.1 kDa	Yes	7
GABBR1-015 ENSP00000419755 ENST00000462632	C9JZG6 [Direct mapping] Gamma-aminobutyric acid type B receptor subunit 1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all		156 aa 17.2 kDa	Yes	0
GABBR1-016 ENSP00000417332 ENST00000476670	C9J342 [Direct mapping] Gamma-aminobutyric acid type B receptor subunit 1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all		133 aa 14.6 kDa	Yes	0
GABBR1-201 ENSP00000366176 ENST00000376977	Q9UBS5 [Direct mapping] Gamma-aminobutyric acid type B receptor subunit 1 Show all	Family 3 (C) receptors G-protein coupled receptors GPCRs excl olfactory receptors Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins FDA approved drug targets Small molecule drugs Show all	GO:0004965 [G-protein coupled GABA receptor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007193 [adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway] GO:0007194 [negative regulation of adenylate cyclase activity] GO:0007214 [gamma-aminobutyric acid signaling pathway] GO:0007268 [synaptic transmission] GO:0030054 [cell junction] GO:0030425 [dendrite] GO:0038039 [G-protein coupled receptor heterodimeric complex] GO:0045211 [postsynaptic membrane] Show all	578 aa 65.1 kDa	Yes	0

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