Expression of SPDYC in cancer - Summary - The Human Protein Atlas

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SPDYC

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	SPDYC
Gene description	Speedy/RINGO cell cycle regulator family member C
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (breast cancer)
HPA (cell line):	Cell line enhanced (BEWO, HEL, K-562)
HPA (normal tissue):	Tissue enhanced (liver, testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several different tissue types.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining not consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA039891
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PROGNOSTIC SUMMARY
Prognostic marker in breast cancer (unfavourable).
Breast cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (breast cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA039891

GENE INFORMATION
Gene name	SPDYC (HGNC Symbol)
Synonyms	Ringo2
Description	Speedy/RINGO cell cycle regulator family member C (HGNC Symbol)
Entrez gene summary
Chromosome	11
Cytoband	q13.1
Chromosome location (bp)	65170154 - 65173244
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000204710 (version 83.38)
Entrez gene	387778
UniProt	Q5MJ68 (UniProt - Evidence at protein level)
neXtProt	NX_Q5MJ68
Antibodypedia	SPDYC antibodies

PROTEIN BROWSER

SPDYC-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SPDYC-001 ENSP00000366390 ENST00000377185	Q5MJ68 [Direct mapping] Speedy protein C Show all	Predicted intracellular proteins Show all	GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0007049 [cell cycle] GO:0019901 [protein kinase binding] Show all	293 aa 33.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.