Expression of RANBP17 in cancer - Summary - The Human Protein Atlas

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RANBP17

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	RANBP17
Gene description	RAN binding protein 17
Protein class	Cancer-related genes Predicted intracellular proteins Predicted membrane proteins Transporters
Predicted localization	Intracellular,Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Mixed
HPA (normal tissue):	Tissue enhanced (testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification.
Reliability score	Uncertain based on 2 antibodies. HPA029568 , HPA029569
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA029568	HPA029569

GENE INFORMATION
Gene name	RANBP17
Synonyms
Description	RAN binding protein 17 (HGNC Symbol)
Entrez gene summary	The transport of protein and large RNAs through the nuclear pore complexes (NPC) is an energy-dependent and regulated process. The import of proteins with a nuclear localization signal (NLS) is accomplished by recognition of one or more clusters of basic amino acids by the importin-alpha/beta complex; see MIM 600685 and MIM 602738. The small GTPase RAN (MIM 601179) plays a key role in NLS-dependent protein import. RAN-binding protein-17 is a member of the importin-beta superfamily of nuclear transport receptors.[supplied by OMIM, Jul 2002]
Chromosome	5
Cytoband	q35.1
Chromosome location (bp)	170861870 - 171300015
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000204764 (version 83.38)
Entrez gene	64901
UniProt	Q9H2T7 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9H2T7
Antibodypedia	RANBP17 antibodies

PROTEIN BROWSER

RANBP17-001	RANBP17-011	RANBP17-012	RANBP17-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RANBP17-001 ENSP00000427975 ENST00000523189	Q9H2T7 [Direct mapping] Ran-binding protein 17 Q546R4 [Target identity:100%; Query identity:100%] RAN binding protein 17, isoform CRA_b Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005049 [nuclear export signal receptor activity] GO:0005488 [binding] GO:0005525 [GTP binding] GO:0005643 [nuclear pore] GO:0005737 [cytoplasm] GO:0006606 [protein import into nucleus] GO:0006611 [protein export from nucleus] GO:0006886 [intracellular protein transport] GO:0008536 [Ran GTPase binding] GO:0051028 [mRNA transport] Show all	1088 aa 124.4 kDa	No	1
RANBP17-011 ENSP00000429609 ENST00000519944	E5RHX1 [Direct mapping] Ran-binding protein 17 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		38 aa 4.4 kDa	No	0
RANBP17-012 ENSP00000430577 ENST00000522734	H0YBY7 [Direct mapping] Ran-binding protein 17 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005488 [binding] Show all	175 aa 19.8 kDa	No	0
RANBP17-201 ENSP00000478243 ENST00000616486	A0A087WTZ2 [Direct mapping] Ran-binding protein 17 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005488 [binding] Show all	518 aa 59.6 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.