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DCTN1

GENERAL INFORMATION

Gene name

 DCTN1

Gene description

 Dynactin 1

Protein class

 Cancer-related genes
Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 16
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA034635 , CAB009108
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Urinary bladder

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 DCTN1

Synonyms

Description

 Dynactin 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes the largest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. Dynactin is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit interacts with dynein intermediate chain by its domains directly binding to dynein and binds to microtubules via a highly conserved glycine-rich cytoskeleton-associated protein (CAP-Gly) domain in its N-terminus. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause distal hereditary motor neuronopathy type VIIB (HMN7B) which is also known as distal spinal and bulbar muscular atrophy (dSBMA). [provided by RefSeq, Oct 2008]

Chromosome

 2

Cytoband

 p13.1

Chromosome location (bp)

 74361154 - 74392087

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000204843 (version 83.38)

Entrez gene

 1639

UniProt

 Q14203 (UniProt - Evidence at protein level)

neXtProt

 NX_Q14203

Antibodypedia

 DCTN1 antibodies

PROTEIN BROWSER
«
DCTN1-001
DCTN1-002
DCTN1-004
DCTN1-006
DCTN1-007
DCTN1-011
DCTN1-012
DCTN1-013
DCTN1-014
DCTN1-015
DCTN1-016
DCTN1-017
DCTN1-018
DCTN1-028
DCTN1-201
DCTN1-202
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DCTN1-001
ENSP00000354791
ENST00000361874
Q14203 [Direct mapping]
Dynactin subunit 1
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0000776 [kinetochore]
GO:0000922 [spindle pole]
GO:0003774 [motor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0006996 [organelle organization]
GO:0007067 [mitotic nuclear division]
GO:0007399 [nervous system development]
GO:0016020 [membrane]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0030286 [dynein complex]
GO:0030904 [retromer complex]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0031252 [cell leading edge]
GO:0032402 [melanosome transport]
GO:0036498 [IRE1-mediated unfolded protein response]
GO:0042147 [retrograde transport, endosome to Golgi]
GO:0043234 [protein complex]
GO:0044267 [cellular protein metabolic process]
Show all
 1278 aa
141.7 kDa 		No 0
DCTN1-002
ENSP00000386843
ENST00000409567
Q14203 [Direct mapping]
Dynactin subunit 1
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0000776 [kinetochore]
GO:0000922 [spindle pole]
GO:0003774 [motor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0006996 [organelle organization]
GO:0007067 [mitotic nuclear division]
GO:0007399 [nervous system development]
GO:0016020 [membrane]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0030286 [dynein complex]
GO:0030904 [retromer complex]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0036498 [IRE1-mediated unfolded protein response]
GO:0042147 [retrograde transport, endosome to Golgi]
GO:0044267 [cellular protein metabolic process]
Show all
 1253 aa
138.8 kDa 		No 0
DCTN1-004
ENSP00000387270
ENST00000409438
Q14203 [Direct mapping]
Dynactin subunit 1
Show all
   Phobius predicted secreted proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0000776 [kinetochore]
GO:0000922 [spindle pole]
GO:0003774 [motor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0006996 [organelle organization]
GO:0007067 [mitotic nuclear division]
GO:0007399 [nervous system development]
GO:0016020 [membrane]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0030286 [dynein complex]
GO:0030904 [retromer complex]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0036498 [IRE1-mediated unfolded protein response]
GO:0042147 [retrograde transport, endosome to Golgi]
GO:0044267 [cellular protein metabolic process]
Show all
 1139 aa
126.7 kDa 		No 0
DCTN1-006
ENSP00000386406
ENST00000409240
Q14203 [Direct mapping]
Dynactin subunit 1
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0000776 [kinetochore]
GO:0000922 [spindle pole]
GO:0003774 [motor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0006996 [organelle organization]
GO:0007067 [mitotic nuclear division]
GO:0007399 [nervous system development]
GO:0016020 [membrane]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0030286 [dynein complex]
GO:0030904 [retromer complex]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0036498 [IRE1-mediated unfolded protein response]
GO:0042147 [retrograde transport, endosome to Golgi]
GO:0044267 [cellular protein metabolic process]
Show all
 1236 aa
136.8 kDa 		No 0
DCTN1-007
ENSP00000387327
ENST00000409868
E7EX90 [Direct mapping]
Dynactin subunit 1
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
 1256 aa
139.1 kDa 		No 0
DCTN1-011
ENSP00000400059
ENST00000440727
C9J1B7 [Direct mapping]
Dynactin subunit 1
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
 64 aa
6.8 kDa 		No 0
DCTN1-012
ENSP00000402509
ENST00000417090
C9JKG6 [Direct mapping]
Dynactin subunit 1
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
 135 aa
14.4 kDa 		No 0
DCTN1-013
ENSP00000395312
ENST00000437375
C9JJN7 [Direct mapping]
Dynactin subunit 1
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
 87 aa
9.3 kDa 		No 0
DCTN1-014
ENSP00000409363
ENST00000421392
C9JTE5 [Direct mapping]
Dynactin subunit 1
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
 76 aa
8.1 kDa 		No 0
DCTN1-015
ENSP00000407484
ENST00000449655
C9JUI8 [Direct mapping]
Dynactin subunit 1
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
 14 aa
1.4 kDa 		No 0
DCTN1-016
ENSP00000414315
ENST00000458655
E9PCY0 [Direct mapping]
Dynactin subunit 1
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
 186 aa
19.5 kDa 		No 0
DCTN1-017
ENSP00000404038
ENST00000454119
C9JJD0 [Direct mapping]
Dynactin subunit 1
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
 121 aa
12.9 kDa 		No 0
DCTN1-018
ENSP00000413268
ENST00000413111
C9JZA4 [Direct mapping]
Dynactin subunit 1
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
 76 aa
8.1 kDa 		No 0
DCTN1-028
ENSP00000487724
ENST00000633691
Q14203 [Direct mapping]
Dynactin subunit 1
Show all
   Phobius predicted secreted proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0000776 [kinetochore]
GO:0000922 [spindle pole]
GO:0003774 [motor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0006996 [organelle organization]
GO:0007067 [mitotic nuclear division]
GO:0007399 [nervous system development]
GO:0016020 [membrane]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0030286 [dynein complex]
GO:0030904 [retromer complex]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0036498 [IRE1-mediated unfolded protein response]
GO:0042147 [retrograde transport, endosome to Golgi]
GO:0044267 [cellular protein metabolic process]
Show all
 1144 aa
127.4 kDa 		No 0
DCTN1-201
ENSP00000377571
ENST00000394003
Q14203 [Direct mapping]
Dynactin subunit 1
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0000776 [kinetochore]
GO:0000922 [spindle pole]
GO:0003774 [motor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0006996 [organelle organization]
GO:0007067 [mitotic nuclear division]
GO:0007399 [nervous system development]
GO:0016020 [membrane]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0030286 [dynein complex]
GO:0030904 [retromer complex]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0036498 [IRE1-mediated unfolded protein response]
GO:0042147 [retrograde transport, endosome to Golgi]
GO:0044267 [cellular protein metabolic process]
Show all
 1271 aa
140.9 kDa 		No 0
DCTN1-202
ENSP00000487279
ENST00000628224
E7EX90 [Direct mapping]
Dynactin subunit 1
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
 1256 aa
139.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.