Expression of CD177 in cancer - Summary

GENERAL INFORMATION
Gene name	CD177
Gene description	CD177 molecule
Protein class	Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (prostate cancer)
HPA (cell line):	Cell line enriched (RPMI-8226)
HPA (normal tissue):	Group enriched (bone marrow, colon, prostate, rectum)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in a subset of cells in bone marrow and spleen. Membranous expression in colon and rectum.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA041820 , HPA046601
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PROGNOSTIC SUMMARY
Prognostic marker in cervical cancer (favourable).
Cervical cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (prostate cancer)

PROTEIN EXPRESSION

STAINING SUMMARY

HPA041820	HPA046601

GENE INFORMATION
Gene name	CD177 (HGNC Symbol)
Synonyms	HNA2A, NB1, PRV1
Description	CD177 molecule (HGNC Symbol)
Entrez gene summary	This gene encodes a glycosyl-phosphatidylinositol (GPI)-linked cell surface glycoprotein that plays a role in neutrophil activation. The protein can bind platelet endothelial cell adhesion molecule-1 and function in neutrophil transmigration. Mutations in this gene are associated with myeloproliferative diseases. Over-expression of this gene has been found in patients with polycythemia rubra vera. Autoantibodies against the protein may result in pulmonary transfusion reactions, and it may be involved in Wegener's granulomatosis. A related pseudogene, which is adjacent to this gene on chromosome 19, has been identified. [provided by RefSeq, Apr 2014]
Chromosome	19
Cytoband	q13.31
Chromosome location (bp)	43353659 - 43363172
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000204936 (version 83.38)
Entrez gene	57126
UniProt
neXtProt
Antibodypedia	CD177 antibodies

PROTEIN BROWSER

CD177-001	CD177-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CD177-001 ENSP00000479536 ENST00000618265	A0A087WVM2 [Direct mapping] CD177 antigen Show all	MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all		437 aa 46.4 kDa	Yes	0
CD177-002 ENSP00000483817 ENST00000607855	A0A087X113 [Direct mapping] CD177 antigen Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		139 aa 15.1 kDa	Yes	0