Expression of PRSS1 in cancer - Summary

GENERAL INFORMATION
Gene name	PRSS1
Gene description	Protease, serine, 1 (trypsin 1)
Protein class	Cancer-related genes Disease related genes Enzymes Plasma proteins Potential drug targets Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	5
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (pancreatic cancer)
HPA (cell line):	Cell line enhanced (EFO-21, RPMI-8226, U-2 OS)
HPA (normal tissue):	Tissue enriched (pancreas)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective cytoplasmic expression in exocrine cells of pancreas and in a subset of Paneth cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data. Caution, targets protein from more than one gene.
Reliability score	Supported based on 4 antibodies. HPA062452 , HPA063471 , CAB025487 , CAB025538
	SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (unfavourable), thyroid cancer (favourable) and ovarian cancer (favourable).
Endometrial cancer p<0.001 Thyroid cancer p<0.001 Ovarian cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (pancreatic cancer)

PROTEIN EXPRESSION

STAINING SUMMARY

HPA062452	HPA063471	CAB025487	CAB025538

GENE INFORMATION
Gene name	PRSS1 (HGNC Symbol)
Synonyms	TRY1
Description	Protease, serine, 1 (trypsin 1) (HGNC Symbol)
Entrez gene summary	This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is secreted by the pancreas and cleaved to its active form in the small intestine. It is active on peptide linkages involving the carboxyl group of lysine or arginine. Mutations in this gene are associated with hereditary pancreatitis. This gene and several other trypsinogen genes are localized to the T cell receptor beta locus on chromosome 7. [provided by RefSeq, Jul 2008]
Chromosome	7
Cytoband	q34
Chromosome location (bp)	142749468 - 142763997
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000204983 (version 83.38)
Entrez gene	5644
UniProt	P07477 (UniProt - Evidence at protein level)
neXtProt	NX_P07477
Antibodypedia	PRSS1 antibodies

PROTEIN BROWSER

PRSS1-001	PRSS1-003	PRSS1-004	PRSS1-201	PRSS1-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PRSS1-001 ENSP00000308720 ENST00000311737	P07477 [Direct mapping] Trypsin-1 Alpha-trypsin chain 1 Alpha-trypsin chain 2 Show all	Enzymes ENZYME proteins Hydrolases Peptidases Serine-type peptidases SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0006508 [proteolysis] GO:0006766 [vitamin metabolic process] GO:0006767 [water-soluble vitamin metabolic process] GO:0007586 [digestion] GO:0009235 [cobalamin metabolic process] GO:0022617 [extracellular matrix disassembly] GO:0030198 [extracellular matrix organization] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] GO:0070062 [extracellular exosome] GO:0072562 [blood microparticle] Show all	247 aa 26.6 kDa	Yes	0
PRSS1-003 ENSP00000417854 ENST00000486171	E7EQ64 [Direct mapping] Trypsin-1 Show all	SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0005615 [extracellular space] GO:0006508 [proteolysis] GO:0007586 [digestion] Show all	261 aa 28.1 kDa	Yes	0
PRSS1-004 ENSP00000419912 ENST00000492062	H0Y8D1 [Direct mapping] Trypsin-1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0005615 [extracellular space] GO:0006508 [proteolysis] GO:0007586 [digestion] Show all	142 aa 15.4 kDa	No	0
PRSS1-201 ENSP00000479959 ENST00000612126	A0A087WW55 [Direct mapping] Trypsin-1 Show all	SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0005615 [extracellular space] GO:0006508 [proteolysis] GO:0007586 [digestion] Show all	247 aa 26.6 kDa	Yes	0
PRSS1-202 ENSP00000481361 ENST00000619214	A6XGL3 [Direct mapping] Protease serine 1; Trypsin-1 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0005615 [extracellular space] GO:0006508 [proteolysis] GO:0007586 [digestion] Show all	237 aa 25.4 kDa	Yes	0