Expression of TMEM231 in cancer - Summary

GENERAL INFORMATION
Gene name	TMEM231
Gene description	Transmembrane protein 231
Protein class	Disease related genes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Mixed
HPA (normal tissue):	Tissue enriched (fallopian tube)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Expression in ciliated cells in fallopian tube, respiratory tract and endometrial glands.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data. Protein expression in respiratory epithelia can be correlated with lung RNA-seq data.
Reliability score	Supported based on 1 antibody. HPA042081
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

STAINING SUMMARY

HPA042081

GENE INFORMATION
Gene name	TMEM231 (HGNC Symbol)
Synonyms	ALYE870, FLJ22167, JBTS20, MKS11, PRO1886
Description	Transmembrane protein 231 (HGNC Symbol)
Entrez gene summary	This gene encodes a transmembrane protein, which is a component of the B9 complex involved in the formation of the diffusion barrier between the cilia and plasma membrane. Mutations in this gene cause Joubert syndrome (JBTS). Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2013]
Chromosome	16
Cytoband	q23.1
Chromosome location (bp)	75536744 - 75556286
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000205084 (version 83.38)
Entrez gene	79583
UniProt	Q9H6L2 (UniProt - Evidence at protein level)
neXtProt	NX_Q9H6L2
Antibodypedia	TMEM231 antibodies

PROTEIN BROWSER

TMEM231-001	TMEM231-004	TMEM231-005	TMEM231-011

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TMEM231-001 ENSP00000258173 ENST00000258173	Q9H6L2 [Direct mapping] Transmembrane protein 231 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0007224 [smoothened signaling pathway] GO:0016021 [integral component of membrane] GO:0035869 [ciliary transition zone] GO:0036038 [TCTN-B9D complex] GO:0042384 [cilium assembly] GO:0060170 [ciliary membrane] Show all	316 aa 36.1 kDa	No	1
TMEM231-004 ENSP00000457254 ENST00000565067	H3BTN6 [Direct mapping] Transmembrane protein 231 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	268 aa 30.8 kDa	No	1
TMEM231-005 ENSP00000476267 ENST00000568377	Q9H6L2 [Direct mapping] Transmembrane protein 231 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0007224 [smoothened signaling pathway] GO:0016021 [integral component of membrane] GO:0035869 [ciliary transition zone] GO:0036038 [TCTN-B9D complex] GO:0042384 [cilium assembly] GO:0060170 [ciliary membrane] Show all	345 aa 39.1 kDa	No	1
TMEM231-011 ENSP00000479977 ENST00000615437	A0A087WW60 [Direct mapping] Transmembrane protein 231 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		54 aa 5.8 kDa	No	0