Expression of CCNI2 in cancer - Summary - The Human Protein Atlas

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CCNI2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CCNI2
Gene description	Cyclin I family, member 2
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (colorectal cancer)
HPA (cell line):	Cell line enriched (MOLT-4)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and/or membranous expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA056288
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PROGNOSTIC SUMMARY
Prognostic marker in colorectal cancer (favourable).
Colorectal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (colorectal cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA056288

GENE INFORMATION
Gene name	CCNI2 (HGNC Symbol)
Synonyms	FLJ16793
Description	Cyclin I family, member 2 (HGNC Symbol)
Entrez gene summary
Chromosome	5
Cytoband	q31.1
Chromosome location (bp)	132747445 - 132754403
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000205089 (version 83.38)
Entrez gene	645121
UniProt	Q6ZMN8 (UniProt - Evidence at transcript level)
neXtProt	NX_Q6ZMN8
Antibodypedia	CCNI2 antibodies

PROTEIN BROWSER

CCNI2-001	CCNI2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CCNI2-001 ENSP00000368005 ENST00000378731	Q6ZMN8 [Direct mapping] Cyclin-I2 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Show all		369 aa 40.6 kDa	No	0
CCNI2-201 ENSP00000478257 ENST00000614847	Q6ZMN8 [Direct mapping] Cyclin-I2 Show all	SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all		385 aa 42.4 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.