Expression of CDKL4 in cancer - Summary - The Human Protein Atlas

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CDKL4

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CDKL4
Gene description	Cyclin-dependent kinase-like 4
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Not detected
HPA (cell line):	Cell line enhanced (HL-60, RT4, SH-SY5Y)
HPA (normal tissue):	Tissue enriched (testis)

Protein evidence

Evidence at transcript level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA067895
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Not detected

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA067895

GENE INFORMATION
Gene name	CDKL4
Synonyms
Description	Cyclin-dependent kinase-like 4 (HGNC Symbol)
Entrez gene summary
Chromosome	2
Cytoband	p22.1
Chromosome location (bp)	39175646 - 39229588
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000205111 (version 83.38)
Entrez gene	344387
UniProt	Q5MAI5 (UniProt - Evidence at transcript level)
neXtProt	NX_Q5MAI5
Antibodypedia	CDKL4 antibodies

PROTEIN BROWSER

CDKL4-001	CDKL4-002	CDKL4-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CDKL4-001 ENSP00000368080 ENST00000378803	Q5MAI5 [Direct mapping] Cyclin-dependent kinase-like 4 Show all	Enzymes ENZYME proteins Transferases Kinases CMGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all	GO:0004672 [protein kinase activity] GO:0004693 [cyclin-dependent protein serine/threonine kinase activity] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0006468 [protein phosphorylation] GO:0051726 [regulation of cell cycle] Show all	315 aa 36.2 kDa	No	0
CDKL4-002 ENSP00000378476 ENST00000395035	Q5MAI5 [Direct mapping] Cyclin-dependent kinase-like 4 Show all	Enzymes ENZYME proteins Transferases Kinases CMGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Show all	GO:0004672 [protein kinase activity] GO:0004693 [cyclin-dependent protein serine/threonine kinase activity] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0006468 [protein phosphorylation] GO:0051726 [regulation of cell cycle] Show all	379 aa 43.4 kDa	No	0
CDKL4-003 ENSP00000389833 ENST00000451199	H7BZI6 [Direct mapping] Cyclin-dependent kinase-like 4 Show all	Predicted intracellular proteins Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	124 aa 14.4 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.