Expression of PDE7A in cancer - Summary - The Human Protein Atlas

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PDE7A

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PDE7A
Gene description	Phosphodiesterase 7A
Protein class	Enzymes FDA approved drug targets Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 2 antibodies. HPA027340 , CAB018770
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and liver cancer (unfavourable).
Renal cancer p<0.001 Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA027340	CAB018770

GENE INFORMATION
Gene name	PDE7A (HGNC Symbol)
Synonyms	HCP1
Description	Phosphodiesterase 7A (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE7 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2011]
Chromosome	8
Cytoband	q13.1
Chromosome location (bp)	65717510 - 65842322
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000205268 (version 83.38)
Entrez gene	5150
UniProt	Q13946 (UniProt - Evidence at protein level)
neXtProt	NX_Q13946
Antibodypedia	PDE7A antibodies

PROTEIN BROWSER

PDE7A-001	PDE7A-003	PDE7A-004	PDE7A-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PDE7A-001 ENSP00000385632 ENST00000401827	Q13946 [Direct mapping] High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A Show all	Enzymes ENZYME proteins Hydrolases THUMBUP predicted membrane proteins Predicted intracellular proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Show all	GO:0004112 [cyclic-nucleotide phosphodiesterase activity] GO:0004114 [3',5'-cyclic-nucleotide phosphodiesterase activity] GO:0004115 [3',5'-cyclic-AMP phosphodiesterase activity] GO:0005829 [cytosol] GO:0006198 [cAMP catabolic process] GO:0007165 [signal transduction] GO:0008081 [phosphoric diester hydrolase activity] GO:0019933 [cAMP-mediated signaling] GO:0046872 [metal ion binding] Show all	482 aa 55.5 kDa	No	0
PDE7A-003 ENSP00000368730 ENST00000379419	Q13946 [Direct mapping] High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A Show all	Enzymes ENZYME proteins Hydrolases MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Show all	GO:0004114 [3',5'-cyclic-nucleotide phosphodiesterase activity] GO:0004115 [3',5'-cyclic-AMP phosphodiesterase activity] GO:0005829 [cytosol] GO:0006198 [cAMP catabolic process] GO:0007165 [signal transduction] GO:0008081 [phosphoric diester hydrolase activity] GO:0046872 [metal ion binding] Show all	456 aa 52.7 kDa	Yes	0
PDE7A-004 ENSP00000379881 ENST00000396642	Q13946 [Direct mapping] High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A Show all	Enzymes ENZYME proteins Hydrolases THUMBUP predicted membrane proteins Predicted intracellular proteins FDA approved drug targets Small molecule drugs Show all	GO:0004114 [3',5'-cyclic-nucleotide phosphodiesterase activity] GO:0004115 [3',5'-cyclic-AMP phosphodiesterase activity] GO:0005829 [cytosol] GO:0006198 [cAMP catabolic process] GO:0007165 [signal transduction] GO:0008081 [phosphoric diester hydrolase activity] GO:0046872 [metal ion binding] Show all	424 aa 48.8 kDa	No	0
PDE7A-005 ENSP00000430262 ENST00000523253	E5RG23 [Direct mapping] High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Show all		86 aa 10 kDa	Yes	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.