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Several cases of colorectal and liver cancers along with a few cases of ovarian, breast, lung, thyroid, gastric and pancreatic cancers displayed moderate membranous and/or cytoplasmic positivity. Occasional cases of endometrial, lung, breast and pancreatic cancers were strongly stained. Remaining malignant cells were generally negative.
GENE INFORMATION
Gene name
NT5M (HGNC Symbol)
Synonyms
dNT-2, dNT2, mdN
Description
5',3'-nucleotidase, mitochondrial (HGNC Symbol)
Entrez gene summary
This gene encodes a 5' nucleotidase that localizes to the mitochondrial matrix. This enzyme dephosphorylates the 5'- and 2'(3')-phosphates of uracil and thymine deoxyribonucleotides. The gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]