Expression of ADGRG1 in cancer - Summary

GENERAL INFORMATION
Gene name	ADGRG1
Gene description	Adhesion G protein-coupled receptor G1
Protein class	Disease related genes G-protein coupled receptors Potential drug targets Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	61
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and nuclear expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA046065
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and head and neck cancer (unfavourable).
Renal cancer p<0.001 Head and neck cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA046065

GENE INFORMATION
Gene name	ADGRG1 (HGNC Symbol)
Synonyms	GPR56, TM7LN4, TM7XN1
Description	Adhesion G protein-coupled receptor G1 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the G protein-coupled receptor family and regulates brain cortical patterning. The encoded protein binds specifically to transglutaminase 2, a component of tissue and tumor stroma implicated as an inhibitor of tumor progression. Mutations in this gene are associated with a brain malformation known as bilateral frontoparietal polymicrogyria. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
Chromosome	16
Cytoband	q21
Chromosome location (bp)	57610652 - 57665580
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000205336 (version 83.38)
Entrez gene	9289
UniProt	Q9Y653 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y653
Antibodypedia	ADGRG1 antibodies

PROTEIN BROWSER

ADGRG1-001	ADGRG1-002	ADGRG1-004	ADGRG1-005	ADGRG1-006	ADGRG1-007	ADGRG1-009	ADGRG1-010	ADGRG1-011	ADGRG1-014	ADGRG1-015	ADGRG1-016	ADGRG1-017	ADGRG1-018	ADGRG1-019	ADGRG1-020	ADGRG1-021	ADGRG1-022	ADGRG1-023	ADGRG1-024	ADGRG1-025	ADGRG1-026	ADGRG1-027	ADGRG1-028	ADGRG1-029	ADGRG1-030	ADGRG1-031	ADGRG1-032	ADGRG1-033	ADGRG1-034	ADGRG1-035	ADGRG1-036	ADGRG1-037	ADGRG1-047	ADGRG1-048	ADGRG1-049	ADGRG1-050	ADGRG1-051	ADGRG1-052	ADGRG1-053	ADGRG1-054	ADGRG1-055	ADGRG1-056	ADGRG1-057	ADGRG1-058	ADGRG1-059	ADGRG1-060	ADGRG1-061	ADGRG1-063	ADGRG1-064	ADGRG1-065	ADGRG1-066	ADGRG1-067	ADGRG1-068	ADGRG1-069	ADGRG1-070	ADGRG1-071	ADGRG1-072	ADGRG1-074	ADGRG1-075	ADGRG1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ADGRG1-001 ENSP00000455215 ENST00000568909	Q9Y653 [Direct mapping] G-protein coupled receptor 56 GPR56 N-terminal fragment GPR56 C-terminal fragment A0A024R6U7 [Target identity:100%; Query identity:100%] G protein-coupled receptor 56, isoform CRA_b Show all	G-protein coupled receptors GPCRs excl olfactory receptors Family 2 (B) receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0001525 [angiogenesis] GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0005518 [collagen binding] GO:0005622 [intracellular] GO:0005887 [integral component of plasma membrane] GO:0007155 [cell adhesion] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007266 [Rho protein signal transduction] GO:0007267 [cell-cell signaling] GO:0007420 [brain development] GO:0008285 [negative regulation of cell proliferation] GO:0010573 [vascular endothelial growth factor production] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0021796 [cerebral cortex regionalization] GO:0021801 [cerebral cortex radial glia guided migration] GO:0021819 [layer formation in cerebral cortex] GO:0035025 [positive regulation of Rho protein signal transduction] GO:0045785 [positive regulation of cell adhesion] GO:0050840 [extracellular matrix binding] GO:0070062 [extracellular exosome] GO:0070528 [protein kinase C signaling] GO:0097451 [glial limiting end-foot] GO:2000179 [positive regulation of neural precursor cell proliferation] GO:2001223 [negative regulation of neuron migration] Show all	693 aa 77.7 kDa	Yes	7
ADGRG1-002 ENSP00000456794 ENST00000567835	Q9Y653 [Direct mapping] G-protein coupled receptor 56 GPR56 N-terminal fragment GPR56 C-terminal fragment A0A024R6U7 [Target identity:100%; Query identity:100%] G protein-coupled receptor 56, isoform CRA_b Show all	G-protein coupled receptors GPCRs excl olfactory receptors Family 2 (B) receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001525 [angiogenesis] GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0005518 [collagen binding] GO:0005622 [intracellular] GO:0005887 [integral component of plasma membrane] GO:0007155 [cell adhesion] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007266 [Rho protein signal transduction] GO:0007267 [cell-cell signaling] GO:0007420 [brain development] GO:0008285 [negative regulation of cell proliferation] GO:0010573 [vascular endothelial growth factor production] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0021801 [cerebral cortex radial glia guided migration] GO:0021819 [layer formation in cerebral cortex] GO:0035025 [positive regulation of Rho protein signal transduction] GO:0045785 [positive regulation of cell adhesion] GO:0050840 [extracellular matrix binding] GO:0070062 [extracellular exosome] GO:0070528 [protein kinase C signaling] GO:0097451 [glial limiting end-foot] GO:2001223 [negative regulation of neuron migration] Show all	693 aa 77.7 kDa	Yes	7
ADGRG1-004 ENSP00000457456 ENST00000568908	Q9Y653 [Direct mapping] G-protein coupled receptor 56 GPR56 N-terminal fragment GPR56 C-terminal fragment Show all	G-protein coupled receptors GPCRs excl olfactory receptors Family 2 (B) receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001525 [angiogenesis] GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0005518 [collagen binding] GO:0005622 [intracellular] GO:0005887 [integral component of plasma membrane] GO:0007155 [cell adhesion] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007266 [Rho protein signal transduction] GO:0007267 [cell-cell signaling] GO:0007420 [brain development] GO:0008285 [negative regulation of cell proliferation] GO:0010573 [vascular endothelial growth factor production] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0021801 [cerebral cortex radial glia guided migration] GO:0021819 [layer formation in cerebral cortex] GO:0035025 [positive regulation of Rho protein signal transduction] GO:0045785 [positive regulation of cell adhesion] GO:0050840 [extracellular matrix binding] GO:0070062 [extracellular exosome] GO:0070528 [protein kinase C signaling] GO:0097451 [glial limiting end-foot] GO:2001223 [negative regulation of neuron migration] Show all	687 aa 77.1 kDa	Yes	7
ADGRG1-005 ENSP00000455351 ENST00000562631	Q9Y653 [Direct mapping] G-protein coupled receptor 56 GPR56 N-terminal fragment GPR56 C-terminal fragment Show all	G-protein coupled receptors GPCRs excl olfactory receptors Family 2 (B) receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001525 [angiogenesis] GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0005518 [collagen binding] GO:0005622 [intracellular] GO:0005887 [integral component of plasma membrane] GO:0007155 [cell adhesion] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007266 [Rho protein signal transduction] GO:0007267 [cell-cell signaling] GO:0007420 [brain development] GO:0008285 [negative regulation of cell proliferation] GO:0010573 [vascular endothelial growth factor production] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0021801 [cerebral cortex radial glia guided migration] GO:0021819 [layer formation in cerebral cortex] GO:0035025 [positive regulation of Rho protein signal transduction] GO:0045785 [positive regulation of cell adhesion] GO:0050840 [extracellular matrix binding] GO:0070062 [extracellular exosome] GO:0070528 [protein kinase C signaling] GO:0097451 [glial limiting end-foot] GO:2001223 [negative regulation of neuron migration] Show all	687 aa 77.1 kDa	Yes	7
ADGRG1-006 ENSP00000456620 ENST00000562558	Q9Y653 [Direct mapping] G-protein coupled receptor 56 GPR56 N-terminal fragment GPR56 C-terminal fragment Show all	G-protein coupled receptors GPCRs excl olfactory receptors Family 2 (B) receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001525 [angiogenesis] GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0005518 [collagen binding] GO:0005622 [intracellular] GO:0005887 [integral component of plasma membrane] GO:0007155 [cell adhesion] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007266 [Rho protein signal transduction] GO:0007267 [cell-cell signaling] GO:0007420 [brain development] GO:0008285 [negative regulation of cell proliferation] GO:0010573 [vascular endothelial growth factor production] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0021801 [cerebral cortex radial glia guided migration] GO:0021819 [layer formation in cerebral cortex] GO:0035025 [positive regulation of Rho protein signal transduction] GO:0045785 [positive regulation of cell adhesion] GO:0050840 [extracellular matrix binding] GO:0070062 [extracellular exosome] GO:0070528 [protein kinase C signaling] GO:0097451 [glial limiting end-foot] GO:2001223 [negative regulation of neuron migration] Show all	687 aa 77.1 kDa	Yes	7
ADGRG1-007 ENSP00000373465 ENST00000388813	Q9Y653 [Direct mapping] G-protein coupled receptor 56 GPR56 N-terminal fragment GPR56 C-terminal fragment Show all	G-protein coupled receptors GPCRs excl olfactory receptors Family 2 (B) receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001525 [angiogenesis] GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0005518 [collagen binding] GO:0005622 [intracellular] GO:0005887 [integral component of plasma membrane] GO:0007155 [cell adhesion] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007266 [Rho protein signal transduction] GO:0007267 [cell-cell signaling] GO:0007420 [brain development] GO:0008285 [negative regulation of cell proliferation] GO:0010573 [vascular endothelial growth factor production] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0021801 [cerebral cortex radial glia guided migration] GO:0021819 [layer formation in cerebral cortex] GO:0035025 [positive regulation of Rho protein signal transduction] GO:0045785 [positive regulation of cell adhesion] GO:0050840 [extracellular matrix binding] GO:0070062 [extracellular exosome] GO:0070528 [protein kinase C signaling] GO:0097451 [glial limiting end-foot] GO:2001223 [negative regulation of neuron migration] Show all	687 aa 77.1 kDa	Yes	7
ADGRG1-009 ENSP00000444911 ENST00000540164	Q9Y653 [Direct mapping] G-protein coupled receptor 56 GPR56 N-terminal fragment GPR56 C-terminal fragment Show all	G-protein coupled receptors GPCRs excl olfactory receptors Family 2 (B) receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001525 [angiogenesis] GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0005518 [collagen binding] GO:0005622 [intracellular] GO:0005887 [integral component of plasma membrane] GO:0007155 [cell adhesion] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007266 [Rho protein signal transduction] GO:0007267 [cell-cell signaling] GO:0007420 [brain development] GO:0008285 [negative regulation of cell proliferation] GO:0010573 [vascular endothelial growth factor production] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0021801 [cerebral cortex radial glia guided migration] GO:0021819 [layer formation in cerebral cortex] GO:0035025 [positive regulation of Rho protein signal transduction] GO:0045785 [positive regulation of cell adhesion] GO:0050840 [extracellular matrix binding] GO:0070062 [extracellular exosome] GO:0070528 [protein kinase C signaling] GO:0097451 [glial limiting end-foot] GO:2001223 [negative regulation of neuron migration] Show all	687 aa 77.1 kDa	Yes	7
ADGRG1-010 ENSP00000456781 ENST00000565587	H3BSN3 [Direct mapping] Protein ADGRG1 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		50 aa 5.9 kDa	Yes	0
ADGRG1-011 ENSP00000456731 ENST00000565391	H3BSJ6 [Direct mapping] Protein ADGRG1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	187 aa 21 kDa	No	1
ADGRG1-014 ENSP00000454233 ENST00000568618	H3BNN3 [Direct mapping] Protein ADGRG1 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		94 aa 10.8 kDa	Yes	0
ADGRG1-015 ENSP00000456147 ENST00000563414	H3BRA1 [Direct mapping] Protein ADGRG1 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		111 aa 12.9 kDa	Yes	0
ADGRG1-016 ENSP00000457223 ENST00000564360	H3BTK9 [Direct mapping] Protein ADGRG1 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		100 aa 11.5 kDa	Yes	0
ADGRG1-017 ENSP00000458087 ENST00000568074	H3BVE9 [Direct mapping] Protein ADGRG1 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		84 aa 9.5 kDa	Yes	0
ADGRG1-018 ENSP00000456362 ENST00000569494	H3BQ46 [Direct mapping] Protein ADGRG1 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		167 aa 18.9 kDa	Yes	0
ADGRG1-019 ENSP00000456263 ENST00000566169	H3BRI7 [Direct mapping] Protein ADGRG1 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		154 aa 17.5 kDa	Yes	0
ADGRG1-020 ENSP00000456544 ENST00000569154	H3BS54 [Direct mapping] Protein ADGRG1 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		118 aa 12.1 kDa	Yes	0
ADGRG1-021 ENSP00000454289 ENST00000568157	H3BS94 [Direct mapping] Protein ADGRG1 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		131 aa 15.1 kDa	Yes	0
ADGRG1-022 ENSP00000457178 ENST00000566187	H3BTH7 [Direct mapping] Protein ADGRG1 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		153 aa 17.4 kDa	Yes	0
ADGRG1-023 ENSP00000457635 ENST00000569158	H3BUH2 [Direct mapping] Protein ADGRG1 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		122 aa 14.1 kDa	Yes	0
ADGRG1-024 ENSP00000456599 ENST00000564722	H3BS94 [Direct mapping] Protein ADGRG1 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		131 aa 15.1 kDa	Yes	0
ADGRG1-025 ENSP00000457953 ENST00000569101	H3BV52 [Direct mapping] Protein ADGRG1 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		199 aa 22.6 kDa	Yes	0
ADGRG1-026 ENSP00000457806 ENST00000563862	H3BUU6 [Direct mapping] Protein ADGRG1 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		164 aa 18.5 kDa	Yes	0
ADGRG1-027 ENSP00000456603 ENST00000565770	H3BS98 [Direct mapping] Protein ADGRG1 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		90 aa 9.3 kDa	Yes	0
ADGRG1-028 ENSP00000457994 ENST00000564103	H3BV84 [Direct mapping] Protein ADGRG1 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		68 aa 7.5 kDa	Yes	0
ADGRG1-029 ENSP00000456682 ENST00000568531	H3BSF7 [Direct mapping] Protein ADGRG1 Show all	THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		125 aa 14 kDa	Yes	0
ADGRG1-030 ENSP00000455553 ENST00000568979	H3BQ11 [Direct mapping] Protein ADGRG1 Show all	THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		95 aa 10.9 kDa	Yes	0
ADGRG1-031 ENSP00000457063 ENST00000567915	H3BRI2 [Direct mapping] Protein ADGRG1 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		118 aa 13.5 kDa	Yes	0
ADGRG1-032 ENSP00000456256 ENST00000562467	H3BRI2 [Direct mapping] Protein ADGRG1 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		118 aa 13.5 kDa	Yes	0
ADGRG1-033 ENSP00000455812 ENST00000567553	H3BQJ9 [Direct mapping] Protein ADGRG1 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		91 aa 10.1 kDa	Yes	0
ADGRG1-034 ENSP00000454607 ENST00000562003	H3BMY9 [Direct mapping] Protein ADGRG1 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		146 aa 16.5 kDa	Yes	0
ADGRG1-035 ENSP00000454263 ENST00000563548	H3BM73 [Direct mapping] Protein ADGRG1 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		125 aa 14.2 kDa	Yes	0
ADGRG1-036 ENSP00000458014 ENST00000568234	H3BVA0 [Direct mapping] Protein ADGRG1 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		145 aa 16.4 kDa	Yes	0
ADGRG1-037 ENSP00000454855 ENST00000566271	H3BNH4 [Direct mapping] Protein ADGRG1 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		198 aa 22.3 kDa	Yes	0
ADGRG1-047 ENSP00000458063 ENST00000561833	H3BVD3 [Direct mapping] Protein ADGRG1 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		162 aa 18.4 kDa	Yes	0
ADGRG1-048 ENSP00000457979 ENST00000569372	H3BV72 [Direct mapping] Protein ADGRG1 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		110 aa 12.8 kDa	Yes	0
ADGRG1-049 ENSP00000454364 ENST00000565013	H3BMF8 [Direct mapping] Protein ADGRG1 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		119 aa 13.7 kDa	Yes	0
ADGRG1-050 ENSP00000455600 ENST00000561696	H3BQ46 [Direct mapping] Protein ADGRG1 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		167 aa 18.9 kDa	Yes	0
ADGRG1-051 ENSP00000456632 ENST00000567154	H3BSB8 [Direct mapping] Protein ADGRG1 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		116 aa 13.4 kDa	Yes	0
ADGRG1-052 ENSP00000455074 ENST00000566164	H3BSB8 [Direct mapping] Protein ADGRG1 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		116 aa 13.4 kDa	Yes	0
ADGRG1-053 ENSP00000456494 ENST00000562414	H3BS14 [Direct mapping] Protein ADGRG1 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		42 aa 4.9 kDa	Yes	0
ADGRG1-054 ENSP00000456787 ENST00000567702	H3BSN7 [Direct mapping] Protein ADGRG1 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		107 aa 12.4 kDa	Yes	0
ADGRG1-055 ENSP00000457122 ENST00000565338	H3BTD2 [Direct mapping] Protein ADGRG1 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		56 aa 6.6 kDa	Yes	0
ADGRG1-056 ENSP00000456002 ENST00000561969	H3BQZ1 [Direct mapping] Protein ADGRG1 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		160 aa 18.1 kDa	Yes	0
ADGRG1-057 ENSP00000457073 ENST00000563445	H3BT88 [Direct mapping] Protein ADGRG1 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		113 aa 13.1 kDa	Yes	0
ADGRG1-058 ENSP00000457143 ENST00000566123	H3BVE9 [Direct mapping] Protein ADGRG1 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		84 aa 9.5 kDa	Yes	0
ADGRG1-059 ENSP00000455176 ENST00000561782	H3BP67 [Direct mapping] Protein ADGRG1 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		168 aa 18.9 kDa	Yes	0
ADGRG1-060 ENSP00000456819 ENST00000562682	H3BSR1 [Direct mapping] Protein ADGRG1 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		77 aa 8.7 kDa	Yes	0
ADGRG1-061 ENSP00000457307 ENST00000569531	H3BMF8 [Direct mapping] Protein ADGRG1 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		119 aa 13.7 kDa	Yes	0
ADGRG1-063 ENSP00000456469 ENST00000565314	H3BRZ4 [Direct mapping] Protein ADGRG1 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		141 aa 16 kDa	Yes	0
ADGRG1-064 ENSP00000454321 ENST00000568791	H3BMC2 [Direct mapping] Protein ADGRG1 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		81 aa 9.1 kDa	Yes	0
ADGRG1-065 ENSP00000456238 ENST00000561988	H3BRH0 [Direct mapping] Protein ADGRG1 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		256 aa 29 kDa	Yes	0
ADGRG1-066 ENSP00000454490 ENST00000564783		Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		6 aa 0.7 kDa	No	0
ADGRG1-067 ENSP00000454933 ENST00000565976	H3BNN3 [Direct mapping] Protein ADGRG1 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		94 aa 10.8 kDa	Yes	0
ADGRG1-068 ENSP00000455965 ENST00000564729	H3BQW4 [Direct mapping] Protein ADGRG1 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		55 aa 6.4 kDa	Yes	0
ADGRG1-069 ENSP00000454779 ENST00000566508	H3BPC0 [Direct mapping] Protein ADGRG1 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		97 aa 10.1 kDa	Yes	0
ADGRG1-070 ENSP00000455209 ENST00000563374	H3BP94 [Direct mapping] Protein ADGRG1 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		78 aa 8.8 kDa	Yes	0
ADGRG1-071 ENSP00000456166 ENST00000570044	H3BRB4 [Direct mapping] Protein ADGRG1 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		70 aa 8 kDa	Yes	0
ADGRG1-072 ENSP00000456796 ENST00000566778	H3BSP5 [Direct mapping] Protein ADGRG1 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		103 aa 11.7 kDa	Yes	0
ADGRG1-074 ENSP00000457657 ENST00000564338	H3BUI6 [Direct mapping] Protein ADGRG1 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		114 aa 13 kDa	Yes	0
ADGRG1-075 ENSP00000455226 ENST00000567397	H3BPA6 [Direct mapping] Protein ADGRG1 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		98 aa 11.1 kDa	Yes	0
ADGRG1-201 ENSP00000398034 ENST00000456916	Q9Y653 [Direct mapping] G-protein coupled receptor 56 GPR56 N-terminal fragment GPR56 C-terminal fragment Show all	G-protein coupled receptors GPCRs excl olfactory receptors Family 2 (B) receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001525 [angiogenesis] GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0005518 [collagen binding] GO:0005622 [intracellular] GO:0005887 [integral component of plasma membrane] GO:0007155 [cell adhesion] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007266 [Rho protein signal transduction] GO:0007267 [cell-cell signaling] GO:0007420 [brain development] GO:0008285 [negative regulation of cell proliferation] GO:0010573 [vascular endothelial growth factor production] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0021801 [cerebral cortex radial glia guided migration] GO:0021819 [layer formation in cerebral cortex] GO:0035025 [positive regulation of Rho protein signal transduction] GO:0045785 [positive regulation of cell adhesion] GO:0050840 [extracellular matrix binding] GO:0070062 [extracellular exosome] GO:0070528 [protein kinase C signaling] GO:0097451 [glial limiting end-foot] GO:2001223 [negative regulation of neuron migration] Show all	692 aa 77.5 kDa	Yes	7