Cell atlas - IPO7 - The Human Protein Atlas

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IPO7

TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS MOUSE CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nucleoplasm

Human cell
	Cytosol
	Nucleoplasm

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GENERAL INFORMATION
Gene name	IPO7
Gene description	Importin 7
Protein class	Cancer-related genes Plasma proteins Predicted intracellular proteins Transporters
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol & nucleoplasm.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (validated), Cytosol (validated)
Mouse	Localized to the Nucleoplasm in mouse cells.

DATA RELIABILITY
Reliability score	Validated based on 1 antibody. HPA056590
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol & nucleoplasm.

Main location

Nucleoplasm (validated), Cytosol (validated)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA056590	A-431	Nucleoplasm
	HPA056590	A-431	Cytosol
	HPA056590	U-2 OS	Nucleoplasm
	HPA056590	U-2 OS	Cytosol
	HPA056590	U-251 MG	Nucleoplasm
	HPA056590	U-251 MG	Cytosol

MOUSE CELLS

Main location

Nucleoplasm

Mouse gene

ENSMUSG00000066232 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location
	HPA056590	NIH 3T3	Nucleoplasm

GENE INFORMATION
Gene name	IPO7 (HGNC Symbol)
Synonyms	Imp7, RANBP7
Description	Importin 7 (HGNC Symbol)
Entrez gene summary	The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. Similar to importin-beta, this protein prevents the activation of Ran's GTPase by RanGAP1 and inhibits nucleotide exchange on RanGTP, and also binds directly to nuclear pore complexes where it competes for binding sites with importin-beta and transportin. This protein has a Ran-dependent transport cycle and it can cross the nuclear envelope rapidly and in both directions. At least four importin beta-like transport receptors, namely importin beta itself, transportin, RanBP5 and RanBP7, directly bind and import ribosomal proteins. [provided by RefSeq, Jul 2008]
Chromosome	11
Cytoband	p15.4
Chromosome location (bp)	9384622 - 9448126
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000205339 (version 83.38)
Entrez gene	10527
UniProt	O95373 (UniProt - Evidence at protein level)
neXtProt	NX_O95373
Antibodypedia	IPO7 antibodies

PROTEIN BROWSER

IPO7-001	IPO7-003	IPO7-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
IPO7-001 ENSP00000369042 ENST00000379719	O95373 [Direct mapping] Importin-7 Show all	Transporters Transporter channels and pores MEMSAT3 predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Mutated cancer genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0005488 [binding] GO:0005515 [protein binding] GO:0005643 [nuclear pore] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006606 [protein import into nucleus] GO:0006886 [intracellular protein transport] GO:0007165 [signal transduction] GO:0008536 [Ran GTPase binding] GO:0008565 [protein transporter activity] GO:0016020 [membrane] GO:0016032 [viral process] GO:0030695 [GTPase regulator activity] GO:0042393 [histone binding] GO:0045087 [innate immune response] GO:0050790 [regulation of catalytic activity] Show all	1038 aa 119.5 kDa	No	0
IPO7-003 ENSP00000435235 ENST00000527431	E9PLB2 [Direct mapping] Importin-7 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005488 [binding] GO:0005622 [intracellular] GO:0006886 [intracellular protein transport] GO:0008536 [Ran GTPase binding] Show all	131 aa 15.4 kDa	No	0
IPO7-201 ENSP00000486575 ENST00000630083	E9PLJ0 [Direct mapping] Importin-7 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all		64 aa 7.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.