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IPO7

GENERAL INFORMATION

Gene name

 IPO7

Gene description

 Importin 7

Protein class

 Cancer-related genes
Plasma proteins
Predicted intracellular proteins
Transporters

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic and nuclear expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA019002
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (unfavourable), cervical cancer (unfavourable) and liver cancer (unfavourable).
Pancreatic cancer p<0.001
Cervical cancer p<0.001
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA019002

GENE INFORMATION

Gene name

 IPO7 (HGNC Symbol)

Synonyms

 Imp7, RANBP7

Description

 Importin 7 (HGNC Symbol)

Entrez gene summary

 The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. Similar to importin-beta, this protein prevents the activation of Ran's GTPase by RanGAP1 and inhibits nucleotide exchange on RanGTP, and also binds directly to nuclear pore complexes where it competes for binding sites with importin-beta and transportin. This protein has a Ran-dependent transport cycle and it can cross the nuclear envelope rapidly and in both directions. At least four importin beta-like transport receptors, namely importin beta itself, transportin, RanBP5 and RanBP7, directly bind and import ribosomal proteins. [provided by RefSeq, Jul 2008]

Chromosome

 11

Cytoband

 p15.4

Chromosome location (bp)

 9384622 - 9448126

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000205339 (version 83.38)

Entrez gene

 10527

UniProt

 O95373 (UniProt - Evidence at protein level)

neXtProt

 NX_O95373

Antibodypedia

 IPO7 antibodies

PROTEIN BROWSER
IPO7-001
IPO7-003
IPO7-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
IPO7-001
ENSP00000369042
ENST00000379719
O95373 [Direct mapping]
Importin-7
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Transporters
   Transporter channels and pores
   MEMSAT3 predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutated cancer genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005215 [transporter activity]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005643 [nuclear pore]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006606 [protein import into nucleus]
GO:0006886 [intracellular protein transport]
GO:0007165 [signal transduction]
GO:0008536 [Ran GTPase binding]
GO:0008565 [protein transporter activity]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0030695 [GTPase regulator activity]
GO:0042393 [histone binding]
GO:0045087 [innate immune response]
GO:0050790 [regulation of catalytic activity]
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 1038 aa
119.5 kDa 		No 0
IPO7-003
ENSP00000435235
ENST00000527431
E9PLB2 [Direct mapping]
Importin-7
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Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
Protein evidence (Ezkurdia et al 2014)
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GO:0005488 [binding]
GO:0005622 [intracellular]
GO:0006886 [intracellular protein transport]
GO:0008536 [Ran GTPase binding]
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 131 aa
15.4 kDa 		No 0
IPO7-201
ENSP00000486575
ENST00000630083
E9PLJ0 [Direct mapping]
Importin-7
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Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
Protein evidence (Ezkurdia et al 2014)
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 64 aa
7.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.