Expression of MT1M in cancer - Summary - The Human Protein Atlas

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MT1M

TISSUE

CELL

PATHOLOGY

GENERAL INFORMATION
Gene name	MT1M
Gene description	Metallothionein 1M
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enriched (RPTEC TERT1)
HPA (normal tissue):	Tissue enhanced (adipose tissue)

Protein evidence

Evidence at protein level

ANTIBODY IHC RELIABILITY
Reliability score	Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in melanoma (unfavourable).
Melanoma p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Pending cancer tissue analysis
STAINING SUMMARY

GENE INFORMATION
Gene name	MT1M (HGNC Symbol)
Synonyms	MT1, MT1K
Description	Metallothionein 1M (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the metallothionein superfamily, type 1 family. Metallothioneins have a high content of cysteine residues that bind various heavy metals. These genes are transcriptionally regulated by both heavy metals and glucocorticoids. [provided by RefSeq, Oct 2011]
Chromosome	16
Cytoband	q13
Chromosome location (bp)	56632233 - 56633986
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000205364 (version 83.38)
Entrez gene	4499
UniProt	Q8N339 (UniProt - Inferred from homology)
neXtProt	NX_Q8N339
Antibodypedia	MT1M antibodies

PROTEIN BROWSER

MT1M-001	MT1M-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MT1M-001 ENSP00000369146 ENST00000379818	Q8N339 [Direct mapping] Metallothionein-1M Show all	Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0008270 [zinc ion binding] GO:0045926 [negative regulation of growth] GO:0046872 [metal ion binding] GO:0048471 [perinuclear region of cytoplasm] GO:0071294 [cellular response to zinc ion] Show all	61 aa 6.1 kDa	No	0
MT1M-002 ENSP00000457575 ENST00000570233	H3BUC6 [Direct mapping] Metallothionein Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Show all	GO:0046872 [metal ion binding] Show all	69 aa 7.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.