Expression of CFI in cancer - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

CFI

premium

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CFI
Gene description	Complement factor I
Protein class	Disease related genes Enzymes Plasma proteins Potential drug targets Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	5
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (CAPAN-2, Hep G2, RPTEC TERT1)
HPA (normal tissue):	Tissue enhanced (liver)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Plasma and extracellular matrix positivity in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
Reliability score	Supported based on 3 antibodies. HPA001143 , HPA024061 , CAB016777
	SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in urothelial cancer (unfavourable).
Urothelial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA001143	HPA024061	CAB016777

GENE INFORMATION
Gene name	CFI (HGNC Symbol)
Synonyms	C3b-INA, FI, IF, KAF
Description	Complement factor I (HGNC Symbol)
Entrez gene summary	This gene encodes a serine proteinase that is essential for regulating the complement cascade. The encoded preproprotein is cleaved to produce both heavy and light chains, which are linked by disulfide bonds to form a heterodimeric glycoprotein. This heterodimer can cleave and inactivate the complement components C4b and C3b, and it prevents the assembly of the C3 and C5 convertase enzymes. Defects in this gene cause complement factor I deficiency, an autosomal recessive disease associated with a susceptibility to pyogenic infections. Mutations in this gene have been associated with a predisposition to atypical hemolytic uraemic syndrome, a disease characterized by acute renal failure, microangiopathic hemolytic anemia and thrombocytopenia. Primary glomerulonephritis with immmune deposits is another condition associated with mutation of this gene. [provided by RefSeq, Jul 2008]
Chromosome	4
Cytoband	q25
Chromosome location (bp)	109740694 - 109802179
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000205403 (version 83.38)
Entrez gene	3426
UniProt	P05156 (UniProt - Evidence at protein level)
neXtProt	NX_P05156
Antibodypedia	CFI antibodies

PROTEIN BROWSER

CFI-001	CFI-004	CFI-006	CFI-201	CFI-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CFI-001 ENSP00000427438 ENST00000512148	G3XAM2 [Direct mapping] Complement factor I; Complement factor I, isoform CRA_b Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0005044 [scavenger receptor activity] GO:0005515 [protein binding] GO:0006508 [proteolysis] GO:0006898 [receptor-mediated endocytosis] GO:0016020 [membrane] Show all	576 aa 65.1 kDa	Yes	0
CFI-004 ENSP00000422009 ENST00000510800	D6R9Z8 [Direct mapping] Complement factor I Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005044 [scavenger receptor activity] GO:0005515 [protein binding] GO:0006898 [receptor-mediated endocytosis] GO:0016020 [membrane] Show all	161 aa 18.3 kDa	Yes	0
CFI-006 ENSP00000378131 ENST00000394635	E7ETH0 [Direct mapping] Complement factor I Show all	SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0005044 [scavenger receptor activity] GO:0005515 [protein binding] GO:0006508 [proteolysis] GO:0006898 [receptor-mediated endocytosis] GO:0016020 [membrane] Show all	591 aa 66.6 kDa	Yes	0
CFI-201 ENSP00000378130 ENST00000394634	P05156 [Direct mapping] Complement factor I Complement factor I heavy chain Complement factor I light chain Show all	Enzymes ENZYME proteins Hydrolases Peptidases Serine-type peptidases SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0005044 [scavenger receptor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0006508 [proteolysis] GO:0006898 [receptor-mediated endocytosis] GO:0006958 [complement activation, classical pathway] GO:0016020 [membrane] GO:0030449 [regulation of complement activation] GO:0045087 [innate immune response] GO:0046872 [metal ion binding] GO:0070062 [extracellular exosome] Show all	583 aa 65.7 kDa	Yes	0
CFI-202 ENSP00000483416 ENST00000618244	A0A087X0I2 [Direct mapping] Complement factor I Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005044 [scavenger receptor activity] GO:0005515 [protein binding] GO:0006898 [receptor-mediated endocytosis] GO:0016020 [membrane] Show all	378 aa 42.5 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.