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KRT6A

GENERAL INFORMATION

Gene name

 KRT6A

Gene description

 Keratin 6A, type II

Protein class

 Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enhanced (head and neck cancer)
HPA (cell line):Cell line enriched (hTCEpi)
HPA (normal tissue):Tissue enriched (esophagus)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Distinct cytoplasmic expression in squamous and respiratory epithelia.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

 Supported based on 2 antibodies.
HPA045697 , HPA061168
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PROGNOSTIC SUMMARY
Prognostic marker in lung cancer (unfavourable).
Lung cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (head and neck cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Skin cancer

STAINING SUMMARY
HPA045697
HPA061168

GENE INFORMATION

Gene name

 KRT6A (HGNC Symbol)

Synonyms

 CK6C, CK6D, K6C, K6D, KRT6C, KRT6D

Description

 Keratin 6A, type II (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. As many as six of this type II cytokeratin (KRT6) have been identified; the multiplicity of the genes is attributed to successive gene duplication events. The genes are expressed with family members KRT16 and/or KRT17 in the filiform papillae of the tongue, the stratified epithelial lining of oral mucosa and esophagus, the outer root sheath of hair follicles, and the glandular epithelia. This KRT6 gene in particular encodes the most abundant isoform. Mutations in these genes have been associated with pachyonychia congenita. In addition, peptides from the C-terminal region of the protein have antimicrobial activity against bacterial pathogens. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Oct 2014]

Chromosome

 12

Cytoband

 q13.13

Chromosome location (bp)

 52487174 - 52493257

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000205420 (version 83.38)

Entrez gene

 3853

UniProt

 P02538 (UniProt - Evidence at protein level)

neXtProt

 NX_P02538

Antibodypedia

 KRT6A antibodies

PROTEIN BROWSER
KRT6A-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KRT6A-001
ENSP00000369317
ENST00000330722
P02538 [Direct mapping]
Keratin, type II cytoskeletal 6A
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Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0002009 [morphogenesis of an epithelium]
GO:0002230 [positive regulation of defense response to virus by host]
GO:0005198 [structural molecule activity]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005882 [intermediate filament]
GO:0008284 [positive regulation of cell proliferation]
GO:0016020 [membrane]
GO:0030154 [cell differentiation]
GO:0042060 [wound healing]
GO:0045095 [keratin filament]
GO:0070062 [extracellular exosome]
GO:0098779 [mitophagy in response to mitochondrial depolarization]
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 564 aa
60 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.