Tissue expression of CNEP1R1 - Summary - The Human Protein Atlas

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CNEP1R1

TISSUE

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CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	CNEP1R1
Gene description	CTD nuclear envelope phosphatase 1 regulatory subunit 1
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Mixed
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in most cell types, higher levels in immune cells found in several tissues.

DATA RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA042815
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Mixed
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	CNEP1R1 (HGNC Symbol)
Synonyms	C16orf69, FLJ38101, NEP1-R1, TMEM188
Description	CTD nuclear envelope phosphatase 1 regulatory subunit 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a transmembrane protein that belongs to the Tmemb_18A family. A similar protein in yeast is a component of an endoplasmic reticulum-associated protein phosphatase complex and is thought to play a role in the synthesis of triacylglycerol. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Chromosome	16
Cytoband	q12.1
Chromosome location (bp)	50024410 - 50037088
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000205423 (version 83.38)
Entrez gene	255919
UniProt	Q8N9A8 (UniProt - Evidence at protein level)
neXtProt	NX_Q8N9A8
Antibodypedia	CNEP1R1 antibodies

PROTEIN BROWSER

CNEP1R1-001	CNEP1R1-003	CNEP1R1-005	CNEP1R1-009	CNEP1R1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CNEP1R1-001 ENSP00000405635 ENST00000458059	Q8N9A8 [Direct mapping] Nuclear envelope phosphatase-regulatory subunit 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000278 [mitotic cell cycle] GO:0005515 [protein binding] GO:0005635 [nuclear envelope] GO:0005737 [cytoplasm] GO:0006629 [lipid metabolic process] GO:0007077 [mitotic nuclear envelope disassembly] GO:0010867 [positive regulation of triglyceride biosynthetic process] GO:0016021 [integral component of membrane] GO:0031965 [nuclear membrane] GO:0034504 [protein localization to nucleus] GO:0035307 [positive regulation of protein dephosphorylation] GO:0071595 [Nem1-Spo7 phosphatase complex] Show all	142 aa 16 kDa	No	2
CNEP1R1-003 ENSP00000457787 ENST00000565556	H3BUT5 [Direct mapping] Nuclear envelope phosphatase-regulatory subunit 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] GO:0035307 [positive regulation of protein dephosphorylation] GO:0071595 [Nem1-Spo7 phosphatase complex] Show all	93 aa 10.4 kDa	Yes	1
CNEP1R1-005 ENSP00000454676 ENST00000562576	H3BN40 [Direct mapping] Nuclear envelope phosphatase-regulatory subunit 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] GO:0035307 [positive regulation of protein dephosphorylation] GO:0071595 [Nem1-Spo7 phosphatase complex] Show all	108 aa 12.3 kDa	No	1
CNEP1R1-009 ENSP00000454356 ENST00000566093	H3BMF1 [Direct mapping] Nuclear envelope phosphatase-regulatory subunit 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] GO:0035307 [positive regulation of protein dephosphorylation] GO:0071595 [Nem1-Spo7 phosphatase complex] Show all	80 aa 9 kDa	Yes	1
CNEP1R1-201 ENSP00000394224 ENST00000427478	Q8N9A8 [Direct mapping] Nuclear envelope phosphatase-regulatory subunit 1 B8YCP3 [Target identity:100%; Query identity:100%] TMP125; Uncharacterized protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0000278 [mitotic cell cycle] GO:0005515 [protein binding] GO:0005635 [nuclear envelope] GO:0005737 [cytoplasm] GO:0006629 [lipid metabolic process] GO:0007077 [mitotic nuclear envelope disassembly] GO:0010867 [positive regulation of triglyceride biosynthetic process] GO:0016021 [integral component of membrane] GO:0031965 [nuclear membrane] GO:0034504 [protein localization to nucleus] GO:0035307 [positive regulation of protein dephosphorylation] GO:0071595 [Nem1-Spo7 phosphatase complex] Show all	125 aa 14.3 kDa	No	1

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