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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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KRT81
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PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

KRT81

Gene description

Keratin 81, type II

Protein class

Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Tissue enhanced (breast cancer, cervical cancer)
HPA (cell line):Cell line enhanced (A-431, A549, PC-3, U-251 MG)
HPA (normal tissue):Tissue enhanced (breast)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Distinct cytoplasmic expression in hair cortex.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining consistent with RNA expression data. Caution, targets protein from more than one gene. External characterization data supports antibody staining.

Reliability score

Supported based on 1 antibody.
HPA049778
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PROGNOSTIC SUMMARY

Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Tissue enhanced (breast cancer, cervical cancer)
0.02004006008001.0k1.2k1.4k1.6k1.8k2.0k2.2k2.4k2.6k2.8k3.0kFPKMBreast cancer (BRCA)Cervical cancer (CESC)Colorectal cancer (COAD,READ)Endometrial cancer (UCEC)Glioma (GBM)Head and neck cancer (HNSC)Liver cancer (LIHC)Lung cancer (LUAD,LUSC)Melanoma (SKCM)Ovarian cancer (OV)Pancreatic cancer (PAAD)Prostate cancer (PRAD)Renal cancer (KICH,KIRC,KIRP)Stomach cancer (STAD)Testis cancer (TGCT)Thyroid cancer (THCA)Urothelial cancer (BLCA)

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY

HPA049778

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Essentially all cancers were negative.

GENE INFORMATION

Gene name

KRT81 (HGNC Symbol)

Synonyms

Hb-1, KRTHB1

Description

Keratin 81, type II (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this hair keratin, as well as KRTHB3 and KRTHB6, is found primarily in the hair cortex. Mutations in this gene and KRTHB6 have been observed in patients with a rare dominant hair disease, monilethrix. [provided by RefSeq, Jul 2008]

Chromosome

12

Cytoband

q13.13

Chromosome location (bp)

52285913 - 52291534

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000205426 (version 83.38)

Entrez gene

3887

UniProt

Q14533 (UniProt - Evidence at protein level)

neXtProt

NX_Q14533

Antibodypedia

KRT81 antibodies

PROTEIN BROWSER

KRT81-001
KRT81-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

KRT81-001
ENSP00000369349
ENST00000327741
Q14533 [Direct mapping]
Keratin, type II cuticular Hb1
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Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005198 [structural molecule activity]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005882 [intermediate filament]
GO:0045095 [keratin filament]
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505 aa
54.9 kDa
No 0
KRT81-201
ENSP00000483796
ENST00000615839
A0A087X106 [Direct mapping]
Keratin, type II cuticular Hb1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005198 [structural molecule activity]
GO:0005882 [intermediate filament]
GO:0045095 [keratin filament]
Show all
484 aa
53.1 kDa
No 0

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