Expression of ATP6AP1L in cancer - Summary - The Human Protein Atlas

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ATP6AP1L

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ATP6AP1L
Gene description	ATPase, H+ transporting, lysosomal accessory protein 1-like
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (MOLT-4)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at transcript level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA053771
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA053771

GENE INFORMATION
Gene name	ATP6AP1L
Synonyms
Description	ATPase, H+ transporting, lysosomal accessory protein 1-like (HGNC Symbol)
Entrez gene summary
Chromosome	5
Cytoband	q14.2
Chromosome location (bp)	82279462 - 82386977
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000205464 (version 83.38)
Entrez gene	92270
UniProt	Q52LC2 (UniProt - Evidence at transcript level)
neXtProt	NX_Q52LC2
Antibodypedia	ATP6AP1L antibodies

PROTEIN BROWSER

ATP6AP1L-001	ATP6AP1L-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ATP6AP1L-001 ENSP00000369513 ENST00000380167	Q52LC2 [Direct mapping] V-type proton ATPase subunit S1-like protein A0A024RAQ7 [Target identity:100%; Query identity:100%] Uncharacterized protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0015991 [ATP hydrolysis coupled proton transport] GO:0016021 [integral component of membrane] GO:0033180 [proton-transporting V-type ATPase, V1 domain] GO:0046933 [proton-transporting ATP synthase activity, rotational mechanism] GO:0046961 [proton-transporting ATPase activity, rotational mechanism] Show all	224 aa 25.3 kDa	No	1
ATP6AP1L-201 ENSP00000391381 ENST00000439350	Q52LC2 [Direct mapping] V-type proton ATPase subunit S1-like protein A0A024RAQ7 [Target identity:100%; Query identity:100%] Uncharacterized protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0015991 [ATP hydrolysis coupled proton transport] GO:0016021 [integral component of membrane] GO:0033180 [proton-transporting V-type ATPase, V1 domain] GO:0046933 [proton-transporting ATP synthase activity, rotational mechanism] GO:0046961 [proton-transporting ATPase activity, rotational mechanism] Show all	224 aa 25.3 kDa	No	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.