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TMSB4X

GENERAL INFORMATION

Gene name

 TMSB4X

Gene description

 Thymosin beta 4, X-linked

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
CAB033806
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB033806

GENE INFORMATION

Gene name

 TMSB4X (HGNC Symbol)

Synonyms

 TB4X, TMSB4

Description

 Thymosin beta 4, X-linked (HGNC Symbol)

Entrez gene summary

 This gene encodes an actin sequestering protein which plays a role in regulation of actin polymerization. The protein is also involved in cell proliferation, migration, and differentiation. This gene escapes X inactivation and has a homolog on chromosome Y. [provided by RefSeq, Jul 2008]

Chromosome

 X

Cytoband

 p22.2

Chromosome location (bp)

 12975108 - 12977227

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000205542 (version 83.38)

Entrez gene

 7114

UniProt

 P62328 (UniProt - Evidence at protein level)

neXtProt

 NX_P62328

Antibodypedia

 TMSB4X antibodies

PROTEIN BROWSER
TMSB4X-001
TMSB4X-002
TMSB4X-003
TMSB4X-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TMSB4X-001
ENSP00000370009
ENST00000380635
P62328 [Direct mapping]
Thymosin beta-4 Hematopoietic system regulatory peptide
A2VCK8 [Target identity:100%; Query identity:100%]
Thymosin beta 4, X-linked; Thymosin, beta 4, X-linked, isoform CRA_a; cDNA, FLJ92006, Homo sapiens thymosin, beta 4, X chromosome (TMSB4X), mRNA
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002576 [platelet degranulation]
GO:0003785 [actin monomer binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005856 [cytoskeleton]
GO:0007015 [actin filament organization]
GO:0007596 [blood coagulation]
GO:0030168 [platelet activation]
GO:0031093 [platelet alpha granule lumen]
GO:0042989 [sequestering of actin monomers]
GO:0044822 [poly(A) RNA binding]
Show all
 44 aa
5.1 kDa 		No 0
TMSB4X-002
ENSP00000414376
ENST00000451311
P62328 [Direct mapping]
Thymosin beta-4 Hematopoietic system regulatory peptide
A2VCK8 [Target identity:100%; Query identity:100%]
Thymosin beta 4, X-linked; Thymosin, beta 4, X-linked, isoform CRA_a; cDNA, FLJ92006, Homo sapiens thymosin, beta 4, X chromosome (TMSB4X), mRNA
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002576 [platelet degranulation]
GO:0003785 [actin monomer binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005856 [cytoskeleton]
GO:0007015 [actin filament organization]
GO:0007596 [blood coagulation]
GO:0030168 [platelet activation]
GO:0031093 [platelet alpha granule lumen]
GO:0042989 [sequestering of actin monomers]
GO:0044822 [poly(A) RNA binding]
Show all
 44 aa
5.1 kDa 		No 0
TMSB4X-003
ENSP00000370010
ENST00000380636
P62328 [Direct mapping]
Thymosin beta-4 Hematopoietic system regulatory peptide
A2VCK8 [Target identity:100%; Query identity:100%]
Thymosin beta 4, X-linked; Thymosin, beta 4, X-linked, isoform CRA_a; cDNA, FLJ92006, Homo sapiens thymosin, beta 4, X chromosome (TMSB4X), mRNA
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002576 [platelet degranulation]
GO:0003785 [actin monomer binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005856 [cytoskeleton]
GO:0007015 [actin filament organization]
GO:0007596 [blood coagulation]
GO:0030168 [platelet activation]
GO:0031093 [platelet alpha granule lumen]
GO:0042989 [sequestering of actin monomers]
GO:0044822 [poly(A) RNA binding]
Show all
 44 aa
5.1 kDa 		No 0
TMSB4X-004
ENSP00000370007
ENST00000380633
P62328 [Direct mapping]
Thymosin beta-4 Hematopoietic system regulatory peptide
A2VCK8 [Target identity:100%; Query identity:100%]
Thymosin beta 4, X-linked; Thymosin, beta 4, X-linked, isoform CRA_a; cDNA, FLJ92006, Homo sapiens thymosin, beta 4, X chromosome (TMSB4X), mRNA
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002576 [platelet degranulation]
GO:0003785 [actin monomer binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005856 [cytoskeleton]
GO:0007015 [actin filament organization]
GO:0007596 [blood coagulation]
GO:0030168 [platelet activation]
GO:0031093 [platelet alpha granule lumen]
GO:0042989 [sequestering of actin monomers]
GO:0044822 [poly(A) RNA binding]
Show all
 44 aa
5.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.