Expression of LIN52 in cancer - Summary - The Human Protein Atlas

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LIN52

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	LIN52
Gene description	Lin-52 DREAM MuvB core complex component
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA000900
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable) and head and neck cancer (favourable).
Liver cancer p<0.001 Head and neck cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA000900

GENE INFORMATION
Gene name	LIN52 (HGNC Symbol)
Synonyms	C14orf46
Description	Lin-52 DREAM MuvB core complex component (HGNC Symbol)
Entrez gene summary
Chromosome	14
Cytoband	q24.3
Chromosome location (bp)	74084796 - 74201235
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000205659 (version 83.38)
Entrez gene	91750
UniProt	Q52LA3 (UniProt - Evidence at protein level)
neXtProt	NX_Q52LA3
Antibodypedia	LIN52 antibodies

PROTEIN BROWSER

LIN52-001	LIN52-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LIN52-001 ENSP00000451812 ENST00000555028	Q52LA3 [Direct mapping] Protein lin-52 homolog Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000086 [G2/M transition of mitotic cell cycle] GO:0000278 [mitotic cell cycle] GO:0005654 [nucleoplasm] GO:0006351 [transcription, DNA-templated] GO:0007049 [cell cycle] GO:0051726 [regulation of cell cycle] GO:0070176 [DRM complex] Show all	116 aa 13 kDa	No	0
LIN52-003 ENSP00000452513 ENST00000554938	G3V5T8 [Direct mapping] Protein lin-52 homolog Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006351 [transcription, DNA-templated] GO:0007049 [cell cycle] GO:0070176 [DRM complex] Show all	97 aa 11 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.