Expression of MBD3L4 in cancer - Summary - The Human Protein Atlas

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MBD3L4

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	MBD3L4
Gene description	Methyl-CpG binding domain protein 3-like 4
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Not detected
HPA (cell line):	Not detected
HPA (normal tissue):	Not detected

Protein evidence

No evidence

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Caution, targets protein from more than one gene.
Reliability score	Uncertain based on 1 antibody. HPA051259
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Not detected

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA051259

GENE INFORMATION
Gene name	MBD3L4
Synonyms
Description	Methyl-CpG binding domain protein 3-like 4 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of a family of proteins that are related to methyl-CpG-binding proteins but lack the methyl-CpG binding domain. There is no definitive support for transcription of this locus, and the transcript structure is inferred from other family members. [provided by RefSeq, Aug 2009]
Chromosome	19
Cytoband	p13.2
Chromosome location (bp)	7037748 - 7040179
Protein evidence	No evidence (all genes)
Ensembl	ENSG00000205718 (version 83.38)
Entrez gene	653656
UniProt	A6NDZ8 (UniProt - Uncertain)
neXtProt	NX_A6NDZ8
Antibodypedia	MBD3L4 antibodies

PROTEIN BROWSER

MBD3L4-001	MBD3L4-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MBD3L4-001 ENSP00000370801 ENST00000381394	A6NDZ8 [Direct mapping] Putative methyl-CpG-binding domain protein 3-like 4 Show all	Predicted intracellular proteins Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0005634 [nucleus] GO:0006346 [methylation-dependent chromatin silencing] GO:0006351 [transcription, DNA-templated] GO:0008327 [methyl-CpG binding] Show all	208 aa 23.1 kDa	No	0
MBD3L4-201 ENSP00000484740 ENST00000619943	A0A087X268 [Direct mapping] Putative methyl-CpG-binding domain protein 3-like 4; Putative methyl-CpG-binding domain protein 3-like 5 Show all	Predicted intracellular proteins Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0005634 [nucleus] GO:0006346 [methylation-dependent chromatin silencing] GO:0008327 [methyl-CpG binding] Show all	204 aa 22.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.