Expression of DENND1C in cancer - Summary - The Human Protein Atlas

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DENND1C

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	DENND1C
Gene description	DENN/MADD domain containing 1C
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (Daudi, HMC-1, U-937)
HPA (normal tissue):	Tissue enhanced (appendix, lymph node, spleen)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective cytoplasmic expression in subsets of immune cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Pending external verification. Presumed off target binding observed and disregarded. Antibody staining in cells/structures not annotated, view images.
Reliability score	Supported based on 2 antibodies. HPA042758 , HPA042839
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable), lung cancer (favourable), urothelial cancer (favourable) and prostate cancer (unfavourable).
Renal cancer p<0.001 Lung cancer p<0.001 Urothelial cancer p<0.001 Prostate cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA042758	HPA042839

GENE INFORMATION
Gene name	DENND1C (HGNC Symbol)
Synonyms	FAM31C, FLJ22757
Description	DENN/MADD domain containing 1C (HGNC Symbol)
Entrez gene summary	Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1C, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 [PubMed 20154091]).[supplied by OMIM, Nov 2010]
Chromosome	19
Cytoband	p13.3
Chromosome location (bp)	6467207 - 6482557
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000205744 (version 83.38)
Entrez gene	79958
UniProt	Q8IV53 (UniProt - Evidence at protein level)
neXtProt	NX_Q8IV53
Antibodypedia	DENND1C antibodies

PROTEIN BROWSER

DENND1C-001	DENND1C-003	DENND1C-005	DENND1C-012	DENND1C-014

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DENND1C-001 ENSP00000370889 ENST00000381480	Q8IV53 [Direct mapping] DENN domain-containing protein 1C Show all	MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005829 [cytosol] GO:0017112 [Rab guanyl-nucleotide exchange factor activity] GO:0030136 [clathrin-coated vesicle] GO:0043547 [positive regulation of GTPase activity] Show all	801 aa 87.1 kDa	No	0
DENND1C-003 ENSP00000467008 ENST00000590173	K7ENM0 [Direct mapping] DENN domain-containing protein 1C Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		141 aa 15.3 kDa	No	0
DENND1C-005 ENSP00000466394 ENST00000588421	K7EM80 [Direct mapping] DENN domain-containing protein 1C Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		88 aa 10.1 kDa	No	0
DENND1C-012 ENSP00000466583 ENST00000590473	K7EMN9 [Direct mapping] DENN domain-containing protein 1C Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		127 aa 13.9 kDa	No	0
DENND1C-014 ENSP00000437805 ENST00000543576	Q8IV53 [Direct mapping] DENN domain-containing protein 1C Show all	MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005829 [cytosol] GO:0017112 [Rab guanyl-nucleotide exchange factor activity] GO:0030136 [clathrin-coated vesicle] GO:0043547 [positive regulation of GTPase activity] Show all	757 aa 82.1 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.