Expression of GAGE1 in cancer - Summary - The Human Protein Atlas

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GAGE1

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	GAGE1
Gene description	G antigen 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Not detected
HPA (cell line):	Group enriched (AN3-CA, K-562)
HPA (normal tissue):	Tissue enriched (testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective expression in spermatogonia.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 1 antibody. HPA043232
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Not detected

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA043232

GENE INFORMATION
Gene name	GAGE1 (HGNC Symbol)
Synonyms	CT4.1
Description	G antigen 1 (HGNC Symbol)
Entrez gene summary	This gene belongs to a family of genes that are expressed in a variety of tumors but not in normal tissues, except for the testis. The sequences of the family members are highly related but differ by scattered nucleotide substitutions. The antigenic peptide YRPRPRRY, which is also encoded by several other family members, is recognized by autologous cytolytic T lymphocytes. Nothing is presently known about the function of this protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]
Chromosome	X
Cytoband	p11.23
Chromosome location (bp)	49589496 - 49608536
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000205777 (version 83.38)
Entrez gene	2543
UniProt	Q13068 (UniProt - Evidence at protein level)
neXtProt	NX_Q13068
Antibodypedia	GAGE1 antibodies

PROTEIN BROWSER

GAGE1-002	GAGE1-201	GAGE1-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GAGE1-002 ENSP00000371119 ENST00000381700	Q13068 [Target identity:100%; Query identity:100%] G antigen 4 Show all	Predicted intracellular proteins Show all		117 aa 12.9 kDa	No	0
GAGE1-201 ENSP00000482230 ENST00000610680	Q13068 [Target identity:100%; Query identity:100%] G antigen 4 Show all	Predicted intracellular proteins Show all		117 aa 12.9 kDa	No	0
GAGE1-202 ENSP00000484668 ENST00000619375	Q13068 [Target identity:100%; Query identity:100%] G antigen 4 Show all	Predicted intracellular proteins Show all		117 aa 12.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.