Expression of DAZ4 in cancer - Summary - The Human Protein Atlas

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DAZ4

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	DAZ4
Gene description	Deleted in azoospermia 4
Protein class	Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Not detected
HPA (cell line):	Group enriched (U-266/70, U-266/84)
HPA (normal tissue):	Group enriched (stomach, testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in testis.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Caution, targets protein from more than one gene. External characterization data supports antibody staining.
Reliability score	Approved based on 1 antibody. HPA047113
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Not detected

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA047113

GENE INFORMATION
Gene name	DAZ4
Synonyms
Description	Deleted in azoospermia 4 (HGNC Symbol)
Entrez gene summary	This gene is a member of the DAZ gene family and is a candidate for the human Y-chromosomal azoospermia factor (AZF). Its expression is restricted to premeiotic germ cells, particularly in spermatogonia. It encodes an RNA-binding protein that is important for spermatogenesis. Four copies of this gene are found on chromosome Y within palindromic duplications; one pair of genes is part of the P2 palindrome and the second pair is part of the P1 palindrome. Each gene contains a 2.4 kb repeat including a 72-bp exon, called the DAZ repeat; the number of DAZ repeats is variable and there are several variations in the sequence of the DAZ repeat. Each copy of the gene also contains a 10.8 kb region that may be amplified; this region includes five exons that encode an RNA recognition motif (RRM) domain. This gene contains two copies of the 10.8 kb repeat. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Feb 2011]
Chromosome	Y
Cytoband	q11.23
Chromosome location (bp)	24833843 - 24907040
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000205916 (version 83.38)
Entrez gene	57135
UniProt	Q86SG3 (UniProt - Evidence at protein level)
neXtProt	NX_Q86SG3
Antibodypedia	DAZ4 antibodies

PROTEIN BROWSER

DAZ4-001	DAZ4-003	DAZ4-004	DAZ4-005	DAZ4-201	DAZ4-202	DAZ4-203

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DAZ4-001 ENSP00000371751 ENST00000382314		Predicted intracellular proteins Show all	GO:0003676 [nucleic acid binding] Show all	603 aa 67.5 kDa	No	0
DAZ4-003 ENSP00000371733 ENST00000382296	E7EU38 [Direct mapping] Deleted in azoospermia protein 4 Show all	Predicted intracellular proteins Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] Show all	651 aa 73 kDa	No	0
DAZ4-004 ENSP00000389300 ENST00000449750	Q86SG3 [Direct mapping] Deleted in azoospermia protein 4 Show all	Predicted intracellular proteins Disease related genes Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0007275 [multicellular organismal development] GO:0007283 [spermatogenesis] GO:0030154 [cell differentiation] Show all	390 aa 44.1 kDa	No	0
DAZ4-005 ENSP00000489430 ENST00000634662		Predicted intracellular proteins Show all	GO:0003676 [nucleic acid binding] Show all	579 aa 64.8 kDa	No	0
DAZ4-201 ENSP00000371869 ENST00000382432	E7ENA5 [Direct mapping] Deleted in azoospermia protein 4 Show all	Predicted intracellular proteins Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] Show all	558 aa 63.1 kDa	No	0
DAZ4-202 ENSP00000397895 ENST00000415508	E7EU39 [Direct mapping] Deleted in azoospermia protein 2; Deleted in azoospermia protein 4 Show all	Predicted intracellular proteins Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] Show all	366 aa 41.3 kDa	No	0
DAZ4-203 ENSP00000401363 ENST00000440066	A0A0A0MSS9 [Direct mapping] Deleted in azoospermia protein 4 Show all	Predicted intracellular proteins Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] Show all	486 aa 55 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.