Expression of C21orf62 in cancer - Summary - The Human Protein Atlas

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C21orf62

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	C21orf62
Gene description	Chromosome 21 open reading frame 62
Protein class	Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (glioma)
HPA (cell line):	Group enriched (AF22, RPTEC TERT1)
HPA (normal tissue):	Tissue enhanced (epididymis, kidney, ovary)

Protein evidence

Evidence at transcript level

Protein expression
normal tissue

Cytoplasmic and membranous expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Pending external verification. Presumed off target binding observed and disregarded.
Reliability score	Approved based on 2 antibodies. HPA016899 , CAB034173
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (glioma)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA016899	CAB034173

GENE INFORMATION
Gene name	C21orf62 (HGNC Symbol)
Synonyms	B37, C21orf120, PRED81
Description	Chromosome 21 open reading frame 62 (HGNC Symbol)
Entrez gene summary
Chromosome	21
Cytoband	q22.11
Chromosome location (bp)	32790674 - 32813743
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000205929 (version 83.38)
Entrez gene	56245
UniProt	Q9NYP8 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9NYP8
Antibodypedia	C21orf62 antibodies

PROTEIN BROWSER

C21orf62-001	C21orf62-002	C21orf62-003	C21orf62-004	C21orf62-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
C21orf62-001 ENSP00000418830 ENST00000490358	Q9NYP8 [Direct mapping] Uncharacterized protein C21orf62 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0003674 [molecular_function] GO:0005575 [cellular_component] GO:0008150 [biological_process] Show all	219 aa 24.9 kDa	Yes	0
C21orf62-002 ENSP00000418653 ENST00000479548	Q9NYP8 [Direct mapping] Uncharacterized protein C21orf62 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0003674 [molecular_function] GO:0005575 [cellular_component] GO:0008150 [biological_process] Show all	219 aa 24.9 kDa	Yes	0
C21orf62-003 ENSP00000418511 ENST00000487113	Q9NYP8 [Direct mapping] Uncharacterized protein C21orf62 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0003674 [molecular_function] GO:0005575 [cellular_component] GO:0008150 [biological_process] Show all	219 aa 24.9 kDa	Yes	0
C21orf62-004 ENSP00000371810 ENST00000382373	H7BYF8 [Direct mapping] Uncharacterized protein C21orf62 Show all	Predicted intracellular proteins Show all		266 aa 30.3 kDa	No	0
C21orf62-201 ENSP00000444950 ENST00000536776	Q9NYP8 [Direct mapping] Uncharacterized protein C21orf62 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0003674 [molecular_function] GO:0005575 [cellular_component] GO:0008150 [biological_process] Show all	219 aa 24.9 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.