Expression of DAZ2 in cancer - Summary - The Human Protein Atlas

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DAZ2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	DAZ2
Gene description	Deleted in azoospermia 2
Protein class	Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Not detected
HPA (cell line):	Cell line enriched (SK-MEL-30)
HPA (normal tissue):	Group enriched (stomach, testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in testis.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Caution, targets protein from more than one gene. External characterization data supports antibody staining.
Reliability score	Approved based on 1 antibody. HPA047113
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Not detected

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA047113

GENE INFORMATION
Gene name	DAZ2 (HGNC Symbol)
Synonyms	MGC126442, pDP1678
Description	Deleted in azoospermia 2 (HGNC Symbol)
Entrez gene summary	This gene is a member of the DAZ gene family and is a candidate for the human Y-chromosomal azoospermia factor (AZF). Its expression is restricted to premeiotic germ cells, particularly in spermatogonia. It encodes an RNA-binding protein that is important for spermatogenesis. Four copies of this gene are found on chromosome Y within palindromic duplications; one pair of genes is part of the P2 palindrome and the second pair is part of the P1 palindrome. Each gene contains a 2.4 kb repeat including a 72-bp exon, called the DAZ repeat; the number of DAZ repeats is variable and there are several variations in the sequence of the DAZ repeat. Each copy of the gene also contains a 10.8 kb region that may be amplified; this region includes five exons that encode an RNA recognition motif (RRM) domain. This gene contains one copy of the 10.8 kb repeat. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Chromosome	Y
Cytoband	q11.223
Chromosome location (bp)	23219434 - 23291356
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000205944 (version 83.38)
Entrez gene	57055
UniProt	Q13117 (UniProt - Evidence at protein level)
neXtProt	NX_Q13117
Antibodypedia	DAZ2 antibodies

PROTEIN BROWSER

DAZ2-001	DAZ2-002	DAZ2-003	DAZ2-201	DAZ2-202	DAZ2-203	DAZ2-204	DAZ2-205	DAZ2-206

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DAZ2-001 ENSP00000371887 ENST00000382449	Q13117 [Direct mapping] Deleted in azoospermia protein 2 Show all	Predicted intracellular proteins Disease related genes Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0007275 [multicellular organismal development] GO:0007283 [spermatogenesis] GO:0007338 [single fertilization] GO:0030154 [cell differentiation] Show all	534 aa 60.4 kDa	No	0
DAZ2-002 ENSP00000371870 ENST00000382433	Q13117 [Direct mapping] Deleted in azoospermia protein 2 Show all	Predicted intracellular proteins Disease related genes Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0007275 [multicellular organismal development] GO:0007283 [spermatogenesis] GO:0007338 [single fertilization] GO:0030154 [cell differentiation] Show all	558 aa 63.1 kDa	No	0
DAZ2-003 ENSP00000371877 ENST00000382440	E9PBY2 [Direct mapping] Deleted in azoospermia protein 2 Show all	Predicted intracellular proteins Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] Show all	654 aa 74.1 kDa	No	0
DAZ2-201 ENSP00000371731 ENST00000382294	E7EU39 [Direct mapping] Deleted in azoospermia protein 2; Deleted in azoospermia protein 4 Show all	Predicted intracellular proteins Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] Show all	366 aa 41.3 kDa	No	0
DAZ2-202 ENSP00000371743 ENST00000382306	Q13117 [Direct mapping] Deleted in azoospermia protein 2 Show all	Predicted intracellular proteins Disease related genes Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0007275 [multicellular organismal development] GO:0007283 [spermatogenesis] GO:0007338 [single fertilization] GO:0030154 [cell differentiation] Show all	534 aa 60.4 kDa	No	0
DAZ2-203 ENSP00000371861 ENST00000382424	Q13117 [Direct mapping] Deleted in azoospermia protein 2 Show all	Predicted intracellular proteins Disease related genes Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0007275 [multicellular organismal development] GO:0007283 [spermatogenesis] GO:0007338 [single fertilization] GO:0030154 [cell differentiation] Show all	558 aa 63.1 kDa	No	0
DAZ2-204 ENSP00000371868 ENST00000382431	I3L0B6 [Direct mapping] Deleted in azoospermia protein 2 Show all	Predicted intracellular proteins Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] Show all	486 aa 55 kDa	No	0
DAZ2-205 ENSP00000383340 ENST00000400493	E7ENA6 [Direct mapping] Deleted in azoospermia protein 2 Show all	Predicted intracellular proteins Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] Show all	438 aa 49.6 kDa	No	0
DAZ2-206 ENSP00000414113 ENST00000449947		Predicted intracellular proteins Show all	GO:0003676 [nucleic acid binding] Show all	390 aa 44.1 kDa	No	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
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