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DNAJC19

GENERAL INFORMATION

Gene name

 DNAJC19

Gene description

 DnaJ (Hsp40) homolog, subfamily C, member 19

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA037782
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PROGNOSTIC SUMMARY
Prognostic marker in ovarian cancer (favourable).
Ovarian cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA037782

GENE INFORMATION

Gene name

 DNAJC19 (HGNC Symbol)

Synonyms

 Pam18, Tim14, TIMM14

Description

 DnaJ (Hsp40) homolog, subfamily C, member 19 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is thought to be part of a complex involved in the ATP-dependent transport of transit peptide-containing proteins from the inner cell membrane to the mitochondrial matrix. Defects in this gene are a cause of 3-methylglutaconic aciduria type 5 (MGA5), also known as dilated cardiomyopathy with ataxia (DCMA). Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1, 2, 6, 10, 14 and 19. [provided by RefSeq, Jan 2012]

Chromosome

 3

Cytoband

 q26.33

Chromosome location (bp)

 180983709 - 180989774

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000205981 (version 83.38)

Entrez gene

 131118

UniProt

 Q96DA6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96DA6

Antibodypedia

 DNAJC19 antibodies

PROTEIN BROWSER
DNAJC19-001
DNAJC19-006
DNAJC19-008
DNAJC19-009

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DNAJC19-001
ENSP00000372005
ENST00000382564
Q96DA6 [Direct mapping]
Mitochondrial import inner membrane translocase subunit TIM14
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   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   TMHMM predicted membrane proteins
   Phobius predicted secreted proteins
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001405 [presequence translocase-associated import motor]
GO:0001671 [ATPase activator activity]
GO:0005515 [protein binding]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0006457 [protein folding]
GO:0006626 [protein targeting to mitochondrion]
GO:0007601 [visual perception]
GO:0008565 [protein transporter activity]
GO:0016021 [integral component of membrane]
GO:0030150 [protein import into mitochondrial matrix]
GO:0032781 [positive regulation of ATPase activity]
GO:0043234 [protein complex]
GO:0044267 [cellular protein metabolic process]
GO:0048806 [genitalia development]
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 116 aa
12.5 kDa 		No 0
DNAJC19-006
ENSP00000419991
ENST00000486355
F2Z3A7 [Direct mapping]
Mitochondrial import inner membrane translocase subunit TIM14
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   SPOCTOPUS predicted membrane proteins
   TMHMM predicted membrane proteins
   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 59 aa
6.3 kDa 		No 0
DNAJC19-008
ENSP00000420767
ENST00000491873
Q96DA6 [Direct mapping]
Mitochondrial import inner membrane translocase subunit TIM14
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001405 [presequence translocase-associated import motor]
GO:0001671 [ATPase activator activity]
GO:0005515 [protein binding]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0006457 [protein folding]
GO:0006626 [protein targeting to mitochondrion]
GO:0007601 [visual perception]
GO:0008565 [protein transporter activity]
GO:0016021 [integral component of membrane]
GO:0030150 [protein import into mitochondrial matrix]
GO:0032781 [positive regulation of ATPase activity]
GO:0043234 [protein complex]
GO:0044267 [cellular protein metabolic process]
GO:0048806 [genitalia development]
Show all
 91 aa
10.1 kDa 		No 0
DNAJC19-009
ENSP00000419191
ENST00000479269
Q96DA6 [Direct mapping]
Mitochondrial import inner membrane translocase subunit TIM14
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001405 [presequence translocase-associated import motor]
GO:0001671 [ATPase activator activity]
GO:0005515 [protein binding]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0006457 [protein folding]
GO:0006626 [protein targeting to mitochondrion]
GO:0007601 [visual perception]
GO:0008565 [protein transporter activity]
GO:0016021 [integral component of membrane]
GO:0030150 [protein import into mitochondrial matrix]
GO:0032781 [positive regulation of ATPase activity]
GO:0043234 [protein complex]
GO:0044267 [cellular protein metabolic process]
GO:0048806 [genitalia development]
Show all
 91 aa
10.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.