Expression of COL6A6 in cancer - Summary - The Human Protein Atlas

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COL6A6

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	COL6A6
Gene description	Collagen, type VI, alpha 6
Protein class	Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (testis cancer)
HPA (cell line):	Not detected
HPA (normal tissue):	Tissue enhanced (lung)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA045239
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (testis cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA045239

GENE INFORMATION
Gene name	COL6A6
Synonyms
Description	Collagen, type VI, alpha 6 (HGNC Symbol)
Entrez gene summary
Chromosome	3
Cytoband	q22.1
Chromosome location (bp)	130560334 - 130678155
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000206384 (version 83.38)
Entrez gene	131873
UniProt	A6NMZ7 (UniProt - Evidence at protein level)
neXtProt	NX_A6NMZ7
Antibodypedia	COL6A6 antibodies

PROTEIN BROWSER

COL6A6-001	COL6A6-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
COL6A6-001 ENSP00000351310 ENST00000358511	A6NMZ7 [Direct mapping] Collagen alpha-6(VI) chain Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005576 [extracellular region] GO:0005578 [proteinaceous extracellular matrix] GO:0005581 [collagen trimer] GO:0007155 [cell adhesion] GO:0022617 [extracellular matrix disassembly] GO:0030198 [extracellular matrix organization] GO:0030574 [collagen catabolic process] Show all	2263 aa 247.2 kDa	Yes	0
COL6A6-003 ENSP00000422921 ENST00000511332	H0Y940 [Direct mapping] Collagen alpha-6(VI) chain Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		259 aa 27.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.